Bas Lendemeijer obtained the doctor’s degree after the public defence of his thesis entiteld ‘Leveraging human induced pluripotent stem cells for modeling brain diseases’ at Erasmus MC on October 5th 2021.
Induced pluripotent stem cell (iPSC)-technology has created the ability to study the development of patient-derived neural cells in vitro and identify cellular phenotypes. The potential of this relatively new field has sparked great interest in the field of neuroscience and beyond. The work presented in this thesis attempts to improve the techniques to differentiate iPSCs towards cells of the neural lineage and demonstrates how these cells can be leveraged to study brain disorders. IPSC technology has provided novel insights into the processes involved in healthy and diseased human brain development.
For the full text of the thesis see https://repub.eur.nl/pub/135706/ (some chapters are still under embargo).
Dr Bas Lendemeijer
