Organ-on-chip technology

Availability of representative in vitro human organ and disease models which incorporate the relevant human genetics and mimic in vivo (disease) tissue environment will be essential to improve development of effective and safe drugs which can specifically target the biology underlying human disease.

The role of stemcells

Today it is possible to create the smallest functional structures of  healthy or diseased tissue/organ on a chip using microfluidics, microelectronics and microfabrication. The innovative approach now is to incorporate human stem cells, adult or pluripotent, derived from healthy individuals or patients with genetic disease into these chips.

Possible uses

‘Organ on Chip’ models  have the potential to reduce drug development costs and failure rates, enable drug repurposing and rescue, reduce time-to-market and minimize the need for animal testing. They will pave the way to human (pre-) clinical trials-on-chips and personalized drugs. Beyond use in drug research by pharma, ‘Organ on Chip’ models will be used as test systems for development of non-pharma treatment approaches, like radiotherapy or hyperthermia for cancer, but also to develop new cosmetics or food additives and for toxicology analysis of environmental contaminants.

Downloads

Towards precision medicine in future healthcare (hDMT White Paper)

Everthing you always wanted to know about organ-on-chip technology and hDMT (but were afraid to ask)

Alles wat je altijd al wilde weten over orgaan-op-een-chip technologie en hDMT (maar nooit durfde te vragen)

hDMT Flyer

 

hDMT History

Towards a new institute