Heart on Chip is an interdisciplinary program to which each partner contributes based on its own ongoing research and clinical interest. Collaboration between partners who complement and reinforce each other in joint projects will create synergy, resulting in innovative ideas and solutions.
Turn into iPS cells
Leiden University Medical Center provides (anonymized) patient samples and corresponding medical histories and turns the patient’s cells into iPS cells, which can be stimulated to form any cell-type of the human body, including heart cells. Using mRNA sequencing technology at the Hubrecht Institute it is possible to analyze molecular profiles at the single cell level, which is important is important to identify pathways and molecular markers that are changed in diseased cells. Pluriomics, a biotech spin-off company of LUMC, is responsible for quality-controlled production of cardiac cells in large quantities and also develops assays for toxicity screening. Through the participation of Galapagos (specialized in drug discovery & development) hDMT stays in contact with the needs of the pharmaceutical industry.
TU Delft, TUe and Philips have expertise on fabricating a true-to-nature physical micro-environment for the heart cells, allowing for mechanical forces such as stretching and electrical stimulation, as well as on advanced sensor technology. The Leiden Academic Centre for Drug Research contributes expertise in metabolomics and mass spectrometry for studying the energy metabolism of the heart muscle cells, in order to gain more insight into cardiac development and the role of metabolic disorders in heart disease.
Twente University contributes expertise on microfluidics and nanotechnology facilitating development of “heart-on-chip” devices. Furthermore, micro-droplet technology enables studying the interaction between two single cells. In collaboration with the Organ-on-a-chip company Mimetas, hDMT can utilize the high throughput microfluidic platform OrganoPlate for the further development of 3D models for study cardiac disease and toxicity.