PLATFORMS

Organ-on-Chip technology platforms

Development of additional platform technology is required for the next generation Organ on Chip models, to improve human cell content, substrates and scaffolds, throughput, readout technologies and complex data analysis.

These platforms are:

  1. 1. Organ-on-Chip readout platform
    1. specific readout technologies are required, e.g. enabling 3D real time monitoring of biochemical/cellular reactions
  2.  
  3. 2. Organ-on-Chip biology platform

- Low/high throughput stem cell differentiation platform
   to discover the right combination of factors for a specific differentiation direction
- Stem cell production platforms
   for high quality production of pluripotent and multipotent stem cells

  1. 3. Organ-on-Chip technology platform
    1. - device platform and manufacturing technologies
    2.    to develop new modules for Organ-on-Chip devices, e.g. new microfluidics,
    3.    microfabrication of porous membranes etc.
    4. ‚Äč- Standardized/artificial extracellular matrix platform
    5.    gels of different degrees of stiffness enabling specific molecules to be coupled and released
    6.  
  2. 4. Organ on Chip data analysis 
    1. - High throughput data analysis platform
      development of complex data analysis software
  3.  
  4. Within these platforms the ‘scalability and manufacturability’ will considered. In order to embed this in an early phase, the activities from the academic groups will incorporate and consult the expertise of the industrial partners.