Postdoctoral researcher on the project: Dissecting the DNA damage response in three dimensional tumor tissue slice cultures


Job description

The Building Blocks of Life sponsored research project entitled “Dissecting the DNA damage response in three dimensional tumor tissue slice cultures” brings together engineers and biomedical researchers from  Erasmus MC (Molecular Genetics), Technical University Delft (Electrical Engineering, Mathematics and Computer Science) and Philips. The central aim of the project is to develop ex vivo culturing of 3D human breast tumor slices in microfluidic devices and exploit this for selection and development of personalized anti-cancer therapies. At Erasmus MC, we will concentrate on incorporating 3D breast tumor specimens in microfluidic (chip) devices developed at TUD and Philips. 


Work environment

A healthy population and excellence in healthcare through research and education. This is what Erasmus MC stands for. Conducting groundbreaking work, pushing boundaries and leading the way. In research, education, and healthcare. We are practical people with a high level of expertise, working hard to improve and renew the healthcare of today and the public health of tomorrow.

The candidate will be positioned at the Department of Molecular Genetics and will work in a research team dedicated to developing 3D (cancer) tissue cultures to study various aspects of the DNA damage response and to exploit this knowledge for improving anti-cancer therapy. The Department of Molecular Genetics is a vibrant and international group of more than 50 researchers working on various aspects of DNA damage, DNA repair and other DNA damage responses. 


Qualifications and skill

• You are a highly motivated candidate with a PhD degree.
• You have received excellent scientific training in the field of Biomedical Sciences, Biology or a related field.
• You have an interest in the (molecular) biology of (breast) cancer and engineering approaches to establish new methods of 3D tissue culture.
• Experience with DNA repair, tissue culture methods and/or engineering will be considered an advantage.

• You have outstanding theoretical and experimental research skills, are well-organized and result-driven with a strong team spirit.
• A strong command of (scientific) English in speech and writing is essential, proven by publications in international journals and presentations at international meetings.

Being able to present a certificate of good conduct is a condition for the appointment.




Terms of employment 

The gross monthly salary amounts a maximum of € 4.842,- (scale 11), depending on your level of education and relevant experience and based on a full-time working week of 36 hours. The terms of employment are in accordance with the Collective Bargaining Agreement for University Medical Centers (CAO UMC). 



For more information about this position, please contact the project leaders:
• Dr Dik van Gent, e-mail:;
• Prof.dr Roland Kanaar, project leaders, e-mail:



Please send your application including Curriculum Vitae and accompanying letter by e-mail to: stating vacancy code 13.21.17.TBW in the subject line.