The Institute for human Organ and Disease Model technologies (hDMT) is a precompetitive non-profit technological R&D institute, initiated in the Netherlands. hDMT integrates state-of-the-art human stem cell technologies with top level engineering, physics, chemistry, biology, clinical and pharmaceutical expertise from academia and industry to develop and valorize human organ and disease models-on-a-chip.
Human test model systems
These miniature models in chip format closely mimic human tissue and organs in vivo. This will primarily meet the need for representative human test model systems for drug development and other applications, and as an additional goal also will reduce the use of animal experiments. hDMT will engage in close dialogue with pharmaceutical and other companies to tune the scientific program to their needs for specific organ and disease models. Within the hDMT Institute also the ‘scalability and manufacturability’ of the technologies will be addressed.
hDMT combines technologies, facilities and expertise from different disciplines and multiple organizations and locations, thereby forming a virtual institute, ‘a laboratory without walls’. hDMT is a public-private consortium of 9 founding partners, including the three Universities of Technology (Twente, Eindhoven, Delft), the Leiden University and University Medical Centre, Erasmus Medical Centre, the Hubrecht Institute, and two companies Genmab and Galapagos. As a central point of contact hDMT is envisaged as the gateway for pharmaceutical companies to ‘Organ on chip’ technology in the Netherlands, supported by world class stem cell science. hDMT will consolidate expertise in the Netherlands and collaborate with experts from abroad in this area to develop complementary international programs that will lead to new insights in human disease, and to new treatments and diagnostic tests.