Author Archives: hDMT

NWO M2 grant ‘LivMetOoC’ for UTwente and Erasmus MC about liver metastasis in a dish

NWO Exact and Natural Sciences has honored twenty-six applications in the Open Competition Science-ENW-M. These grants are intended for innovative, fundamental research of high quality and/or scientific urgency. One of the awarded projects is the project ‘Elucidating how tumor cells build the pre-metastatic liver niche using an advanced liver sinusoid organ-on-chip model – LivMetOoC’ by Séverine Le Gac from the University of Twente together with Wytske van Weerden from Erasmus MC. Two PhD students will bring together the expertise of both groups to develop a micro-liver to investigate which factors play a role in liver metastases. Liver metastasis is a...

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NWO OTP grant ‘SUSTAINER’ for TU Delft about engineered biomaterials for use as cell scaffolds

Gijsje Koenderink of the Bionanoscience Department of TU Delft received an OTP grant from NWO-TTW, together with Jean Marc Daran of the Biotechnology Department of TU Delft. The grant entitled SUSTAINER: Sustainable production of structural proteins for medical and nutritional applications’ aims at the production of extracellular matrix-mimicking biomaterials suitable as cell scaffolds. Current biomaterials are mainly made from animal-derived proteins, limiting their customizability and raising environmental, health and cultural concerns. This project brings together synthetic biologists, materials scientists and companies active in food and biomedical technology with the aim to generate microbial cell factories based on yeast capable of...

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Best scientific micrograph prize for Ahmed Sharaf

Ahmed Sharaf, PhD student in the group of Angelo Accardi (TU Delft), was awarded the best scientific micrograph prize at 48th international Micro and Nanoengineering Conference in Leuven. For more informations about the awards click here.

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Spotlight on animal-free innovations at VU and Amsterdam UMC

Researchers at VU Amsterdam and Amsterdam UMC are working on new methods of research that will reduce animal testing. It’s all part of the initiative Transition to Animal-Free Innovations Amsterdam (TPI Amsterdam). New images from the lab give us a good view of their work. One participant, Professor Bas Teusink (systems biology, VU Amsterdam), is mapping out cell metabolism in order to better predict chemical reactions. While Professor Sue Gibbs (skin and mucosa regenerative medicine, Amsterdam UMC and the Academic Centre for Dentistry Amsterdam (ACTA)) is pioneering the use of skin organoids in the lab: real living skin tissue, which can be used...

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Radboudumc researchers develop human kidney organoids for personalized congenital nephrotic syndrome modeling

Congenital nephrotic syndrome (CNS) is a hallmark of glomerular disease and the result of a defect in specialized cells (podocytes) within the kidney structures that filter the blood (glomeruli). CNS is characterized by massive proteinuria and infants present clinical symptoms early in life, or even before birth. CNS survival prognosis is poor. Patients typically develop end-stage kidney disease between 2 and 8 years old and kidney transplantation is the only effective treatment option available. Podocytes play an important role in the glomerular filtration barrier. Podocytes possess interdigitating foot processes that are bridged by a protein complex called the slit diaphragm,...

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EUROoCS RAB presents resources for Organ-on-Chip validation and qualification at the EUROoCS 2022 Conference

The Regulatory Advisory Board (RAB) of EUROoCS is supporting activities in relation to the regulatory aspect of Organ-on-Chip (OoC) approaches. The RAB has worked closely together with the EU Reference Laboratory for alternatives to animal testing (EURL ECVAM) – an integral part of the European Commission’s Joint Research Centre (JRC) – on compiling a set of resources. This resource list is expected to be used as a reference point for the EUROoCS community in the development of OoC models towards their qualification and regulatory acceptance. The catalogue incorporates two different – but interconnected – set of resources: a carefully selected...

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Awards for Niek Bloks and Marcella van Hoolwerff at OARSI 2022

Niek Bloks and Marcella van Hoolwerff, PhDs from the osteoarthritis research group at the LUMC in Leiden headed by Prof. Ingrid Meulenbelt, were awarded for their ‘highest rated abstract’ during OARSI 2022 in Berlin. In the osteoarthritis research group a human in vitro 3D organoid model has been established in which hiPSCs are differentiated to deposit neo-cartilage with high similarity to autologous cartilage (over 90%). This human model can be applied to study cartilage homeostasis in health and disease and can be used for drug screening purposes. Both, Niek and Marcella used the organoids to gain insight in etio-pathophysiological effects...

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Together again! (editorial june 2022)

Next week on July 4th and 5th the annual EUROoCS conference will be held in Grenoble in France. Xavier Gidrol and Fabrice Navarro from CEA, who are the chairs of EUROoCS 2022, welcome you on behalf of the Scientific Program Committee and the Local Organizing Committee to an exciting face-to-face meeting after two years in remote mode. Over 450 registered participants, much more than expected, will meet at the World Trade Center to exchange results by the 56 oral presentations and 162 posters, listen to the 6 keynote lectures, learn from the special sessions and poster corner, and start new...

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Bring in the Lymph

In the Lymphchip project, a consortium of researchers, engineering companies and pharmacists now takes these chips to the next level by adding a functioning immune system. Valeria Orlova, assistant professor at the Department of Anatomy and Embryology at Leiden University Medical Center and leader of the LymphChip project explains: ‘When we are able to include lymphatics in organ-on-a-chip systems, we will not only have a system that can mimic the immune response of human organs, which will significantly expand their potential applications in research. We will also have a system to study the development and function of the lymphatic system...

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Ariëns award for Christine Mummery

During the FIGON/EUFEPS European Medicines Days 2022 in Leiden on June 2nd 2022, Christine Mummery received the Ariëns award for her work on mini-hearts from stem cells. This award is named after the famous Dutch pharmacologist Prof. Dr. E.J. Ariëns (1918-2002), one of the founders of pharmacology in the Netherlands. After the Ariëns lecture the award was handed over to Christine Mummery by the Dutch Pharmacological Society. Read the full article here (Source Figon magazine June 2022) Source: NVF  

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