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Accelerating the implementation of New Approach Methodologies and other innovative non-animal approaches for the development, testing and production of health technologies Scope: Animals and animal-derived materials are widely used in biomedical research and in the production and development of health technologies. This raises serious ethical concerns, and there is growing societal pressure to move towards alternative approaches and methods. Besides major ethical concerns, there is also scientific evidence that supports moving away from animal-based approaches and finding more human‑relevant methods and strategies for both the assessment of safety and efficacy of new health technologies and for manufacturing. Animal testing requires...
Read moreBio-printing of living cells for regenerative medicine 3D bio-printing is confronted with several challenges that currently hamper its large-scale deployment. Proposals should address most of the following activities: Design the best bio-printing strategy for at least one type of tissue thanks to a better understanding of the interconnections of the different cell types inside the chosen tissue or organ Develop or improve existing equipment able to print bio-constructs with higher resolution in a shorter time using various biomaterials and different cell types Cover all steps of the bio-printing suite, including cell collection, cell differentiation and expansion, imaging, modelling, bio-ink formulation,...
Read moreDeveloping EU methodological frameworks for clinical/performance evaluation and post-market clinical/performance follow-up of medical devices and in vitro diagnostic medical devices (IVDs) Research is needed to help regulators develop common methodological frameworks (including common specifications) on the clinical evidence needed to demonstrate safety, performance and clinical benefit all along the life cycle of devices taking into account the type of device and clinical intended purpose. Such methodological frameworks and standardized approaches are particularly needed for high-risk medical devices, e.g. implantable and class III medical devices, class C and D IVDs, medical device software (including AI enabled devices and next generation sequencing)...
Read moreGaining experience and confidence in New Approach Methodologies (NAM) for regulatory safety and efficacy testing – coordinated training and experience exchange for EU regulators Focus on alternatives to the use of animals for regulatory safety and efficacy testing. Applicants should propose activities that bring together NAM developers and NAM users with European regulators responsible for the safe use of chemicals (e.g. industrial chemicals, pesticides, biocides and cosmetics) and pharmaceuticals in order to inform on NAM solutions available and to encourage the building of a framework on how these NAMs could be most effectively used in the different decision-making contexts. European...
Read moreThe Summit Grant offers research funding for ten years to scientific consortia that have proved in the course of their existing collaboration that they are among the absolute world leaders, or are very close to reaching that status and can make the leap to the very top with the help of this instrument. Consortia can be nominated by the boards of knowledge institutions. Purpose The Summit Grant is intended for scientific consortia that have proved in the course of their existing collaboration that they are among the absolute world leaders, or are very close to reaching that status and can...
Read moreInnovative non-animal human-based tools and strategies for biomedical research Develop and/or use tools and strategies that address critical areas of biomedical research where animal-models are currently used but are of limited translational value for investigation and development of prevention and treatment. Such advanced tools and strategies should aim at a better understanding of the pathogenesis of disorders that feature a high impact on public health and exhibit a high rate of animal use or severe animal suffering and enable to develop biomedical concepts with increased translational value, thereby ultimately leading to improved disease prediction, prevention and treatment. The innovative tools...
Read moreIntegrated, multi-scale computational models of patient patho-physiology (‘virtual twins’) for personalised disease management Develop multi-scale and multi-organ, dynamic, interoperable, modular computational models, capable of accurately simulating the individual patient pathophysiology, spanning different anatomical scales, from the molecular to cell, tissue, organ and systems level, as necessary. Proposals should be multidisciplinary and focus on groups of communicable and/or non-communicable diseases. Goal: improved personalized diagnostics, medicinal devices, and therapeutic strategies tailored to the individual patient pathophysiology. Call: HORIZON-HLTH-2023-TOOL-05-03 (RIA) Total budget: 50 M€ Per project: 8-10 M € Open: 12 January 2023 Deadline: 13 April 2023 More information: Pre-publication work programs Horizon...
Read moreTackling under-researched high-burden medical conditions Call: HORIZON-HLTH-2024-DISEASE-03-14- two-stage Total budget: 25 M€ Per project: 6-7 M € Open: 23 March 2023; Deadline: stage 1, 19 September 2023; stage 2, 11 April 2024 More information: Pre-publication work programs Horizon Europe: Horizon Europe work programmes (europa.eu) see cluster 1 work program
Read moreValidation of fluid-derived biomarkers for the prediction and prevention of brain disorders Call: HORIZON-HLTH-2024-DISEASE-03-13- two-stage Total budget: 25 M€ Per project: 6-8 M € Open: 23 March 2023; Deadline: stage 1, 19 September 2023; stage 2, 11 April 2024 More information: Pre-publication work programs Horizon Europe: Horizon Europe work programmes (europa.eu) see cluster 1 work program
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