Events Archive

10 years of CRACK IT webinar: Putting in vitro platforms at the heart of cardiotoxicity testing

Tue, 13 July 2021, 14:00 - 15:00, Online

This webinar forms part of the CRACK IT 10 year anniversary celebrations and will showcase the technologies and platforms developed to address the 2013 InPulse CRACK IT Challenge to develop a human-based in vitro system to assess cardiotoxicity in new drugs. The Challenge was sponsored by GlaxoSmithKline (GSK).

Professor Chris Denning, Director of the University of Nottingham Biodiscovery Institute and Professor of Stem Cell Biology. Chris led the project team that delivered the Challenge and will describe the various technology platforms developed, their validation and how CRACK IT supported this process. He will also highlight how the technologies have been further developed since the Challenge was completed and their application across different disciplines and sectors.

Dr Peter Clements, Global Head, Comparative and Translational Sciences at GSK. Peter was lead Sponsor of the InPulse Challenge and will describe the rationale behind the Challenge and how GSK will apply the technologies developed to support their decision making relevant to cardiac safety liabilities of new drugs. He will also describe the wider scientific and 3Rs benefits of these models compared to traditional in vitro and in vivo approaches.

Registration and more details see the event website.

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