Events Archive

Keystone Symposium: Organs- and Tissues-on-Chips

Sun, 8 April 2018 - Thu, 12 April 2018, Big Sky Resort, Big Sky, Montana (USA)

This Keystone Symposium is co-organized by Christine Mummery

The meeting will begin on Sunday, April 8 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 12 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, April 13 in order to fully experience the meeting.

Please note that selected Student/Post-doc scholarships are available to cover costs for travel and lodging (deadline for application: December 6).

About the symposium

More than 30% of promising medications have failed in human clinical trials because they are determined to be toxic despite promising pre-clinical studies in 2-D cell culture and animal models. Another 60% fail due to lack of efficacy. Consequently, though several thousand diseases affect humans, only about 500 have approved treatments. However, with the growing understanding of human biology, along with increased availability of innovative technologies, there is now an unprecedented opportunity to translate scientific discoveries more efficiently into new, more effective and safer health interventions.

Organs- or Tissues-on-Chips are innovative, alternative approaches that can enable early indications and potentially more reliable readouts of toxicity and efficacy. These devices employ high-resolution, real-time imaging and non-invasive analysis of biochemical, genetic and metabolic activities of living cells in a functional tissue and organ context. This technology has great potential to advance the study of tissue development, organ physiology and disease etiology. In the context of drug discovery and development, it should be especially valuable for the study of molecular mechanisms of action, prioritization of lead candidates, toxicity testing and biomarker identification. These microfabricated devices have also proven to be useful for modeling human diseases.

This conference will cover ongoing efforts and various applications of tissue-on-chips technology to studies in precision medicine, environmental exposures, reproduction and development, cancer and for use at the International Space Station.

Confirmed speakers

(additional speakers will be added, including short talks chosen from abstracts):
Nancy L. Allbritton, University of North Carolina, Chapel Hill and North Carolina State University, USA
Christopher P. Austin*, National Institutes of Health, USA
Brian R. Berridge, GlaxoSmithKline, USA
Warren M. Casey, NICEATM, NIEHS, National Institutes of Health, USA
Murat Cirit, Massachusetts Institute of Technology, USA
Bruce R. Conklin, Gladstone Institutes and UCSF, USA
Steven George, University of Washington, USA
Linda G. Griffith, Massachusetts Institute of Technology, USA
Geraldine A. Hamilton, Emulate Inc., USA
Kevin E. Healy, University of California, Berkeley, USA
Jonathan Himmelfarb, University of Washington, USA
Helena Therese Hogberg, Johns Hopkins Bloomberg School of Public Health, USA
Donald E. Ingber, Wyss Institute for Biologically Inspired Engineering at Harvard, USA
Uwe Marx, TissUse GmbH and Technische Universitat Berlin, Germany
Donna Mendrick, Food and Drug Administration, USA
Christine L. Mummery, Leiden University Medical Center, Netherlands
Thomas Neumann, Nortis, Inc., USA
Kevin Kit Parker, Harvard University, USA
Richard S. Paules, NIEHS, National Institutes of Health, USA
Adrian Roth, F. Hoffmann-La Roche Ltd, Switzerland
Ivan Rusyn, Texas A&M University, USA
Mark E. Schurdak, University of Pittsburgh, USA
Danilo Tagle, NCATS, National Institutes of Health, USA
D. Lansing Taylor, University of Pittsburgh Drug Discovery Institute, USA
George Truskey, Duke University, USA
Rocky S. Tuan, University of Pittsburgh School of Medicine, USA
Gordana V. Vunjak-Novakovic, Columbia University, USA

*Keynote Speaker

Who should attend?

Bioengineers • Developmental Biologists • Environmental Scientists • Precision Medicine Specialists • Regenerative Medicine Specialists • Regulatory Scientists • Stem Cell Biologists • Toxicologists

Additional Information

view the program
download a program flyer
Deadlines are at midnight US Mountain Time.
Discounted abstract submission and discounted registration save 50 USD and 200 USD, respectively, on later fees.
Presenting a poster is an excellent way to gain feedback on your work. Abstracts can be submitted through the discounted registration deadline for poster presentation, but those submitted by the abstract deadline will also be considered for short talk selection.
Please note that the first advertised meeting date is the date of arrival and registration, and the last date that of the last organized sessions.

Scientific Organizers

Christopher P. Austin, Danilo Tagle, Christine L. Mummery and Brian R. Berridge
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