Upcoming Events

8th Annual Course on the BBB in Drug Development 2017

Wed, 4 October - Fri, 6 October, Uppsala, Sweden

This course addresses the latest insights on role and functions of the Blood-Brain Barrier (BBB) and intra-brain distribution in research concerning drug development regarding drugs aimed for a target within the CNS or drugs aimed to stay outside of the CNS, and will address also CNS drug delivery and CNS diseases. It provides in depth insight in the complex function of the BBB with regard to transport kinetics in health and disease.

There is a high unmet medical need in the treatment of CNS diseases and this problem is getting worse as the number of people suffering from CNS diseases is growing. This implies that there is a huge market for new CNS drugs. However, the development of new CNS drugs is notoriously difficult. For a proper CNS effect the drug should have the ability to cross the BBB and then to reach the relevant target site within the CNS by adequate intra-brain distribution. Also drugs that are aimed to have a peripheral action, but may bear risks for CNS side effects can be better optimized with more knowledge on BBB transport and CNS side effect site distribution.

Thus, knowledge on the physiological and pharmacokinetic aspects of drug delivery to the brain and distribution within the brain compartments is of utmost importance for all drug delivery scientists. Also medicinal chemists need further knowledge on pharmacokinetic principles of CNS distribution to be guided in finding more optimal molecules for CNS action or for the avoidance of CNS side effects.

Who should attend?

This course will be of benefit to researchers from Academia, Big and Small Pharma Industries, Regulatory Agencies and Contract Research Organizations with a need for better understanding of the BBB and factors that determine CNS target site distribution of drugs. A general understanding of physiology and minimal knowledge of differential equations is expected (some information can be provided upon request).

Learning Objectives

After having taken this course, the participants will

  • - have in-depth insight into mechanisms that contribute to BBB transport and intra-brain distribution, with special emphasis on drug delivery and active transport mechanisms
  • - know about the driving forces that determine whether or not a CNS drug will be at the right place, at the right time and at the right concentration
  • - be able to compare and choose between different methods for studying parameters that can be used to understand or even predict BBB transport and CNS distribution
 http://www.bbbcourses.org/registration/
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