Heart disease is at the top of the list of the world’s most serious health problems, as the number of deaths from heart failure is rising and is expected to balloon as the population ages. Currently, most treatments only slow down the progression of the disorder, creating a great need for the development of novel preventative and regenerative therapies. Doing this successfully requires more insight into the molecular and genetic nature of the underlying diseases, which cannot be acquired without human heart disease models.
Animal and cell models have so far failed to capture human heart disease effectively and have poor predictive value for drug responses. Furthermore, primary human heart cells are difficult to obtain and can only be maintained in culture for a short time and is not suitable as a robust testing model. hDMT is therefore pioneering modeling of the heart on (microfluidic) chips based on induced Pluripotent Stem cells (iPSC). The resulting devices can be used for heart disease research, cardiotoxicity screening, drug target discovery and drug efficacy testing.