Organ-on-Chip mini-symposium at UMCG in Groningen

Friday, 4 January

On Wednesday 19th of December, the department of Genetics and the iPSC/CRISPR Center of the UMCG in Groningen organized the 2nd hDMT/UMCG Organ-on-Chip Mini-symposium to illustrate the potential of Organ-on-Chip technology for biomedical research. Three experts in the field presented their work.

Robert Barrett (Cedars-Sinai, Los Angeles) showed the relevance of an intestine-chip model generated from iPSC-derived intestinal organoids to investigate complex immune-mediated intestinal diseases, such as Inflammatory Bowel Disease and Celiac disease. Ben Maoz (Tel Aviv University, Tel Aviv) discussed a human-on-chip system coupling 8 different organs-on-chip (in press) and showed a Blood-Brain-Barrier (BBB) chip combination with which he showed a crucial role for endothelium in BBB biology. Lastly, Loes Segerink (University of Twente, Enschede) showed how sensors can be integrated in chips to accurately measure Trans Epithelial Electrical Resistance (TEER) in a non-invasive and real-time manner.

Cisca Wijmenga (NOCI PI) discussing with Ben Maoz during one of the breaks

The symposium ended with a Meet the Expert lunch, during which visitors had the chance to meet the speakers, and the speakers were engaged before and after their presentations in interactions with several groups at the UMCG that showed interest in setting up collaborations.

Text by Joram Mooiweer and Renée Moerkens, NOCI PhD-students.

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