High quality lectures at the third Annual hDMT Consortium Meeting

Saturday, 9 March 2019

On Friday February 1th, the third annual hDMT Consortium Meeting was held in the Engels Meeting & Conference Center in Rotterdam. Eighty hDMT researchers from PhD to professor attended the program and mingled in discussions. The day was chaired by Femke de Vrij of the Erasmus Medical Center.

The annual hDMT Consortium Meeting is a "closed" meeting and only for researchers from all hDMT partner organizations who are actively involved in hDMT research. It was a full and lively programme with a nice mix of different Organ-on-Chip research topics.

The days programme started with a keynote lecture by Andries van der Meer (University of Twente) on the importance of Organ-on-Chip Platform Technology. Christine Mummery (LUMC) gave an update of the NWO Gravity Program NOCI and all the running activities. Janny van den Eijnden-van Raaij (hDMT) focussed on the hDMT activities in the Netherlands and Europe.

Nine high quality presentations on research highlights (see list below) followed and Nikolas Gaio of the TU Delft and BI/OND closed the day with his insights in development of Organ-on-Silicon devices for OoC research.

Also the hDMT Junior Challenges Call 2019 for junior researchers was launched again. Junior researchers can pitch challenges they have experienced in their research projects and for which they seek collaborators to work on solutions. Hossein Eslami Amirabadi, TNO/UU pitched his challenge on perfusion at higher throughput Organ-on-Chip experiments

hDMT Research Highlights at a glance

  • Heleen Middelkamp (UTwente) Towards a neurovascular-unit-on-a-chip: differentiating neurons from human induced pluripotent stem cells in an open-top microfluidic chip
  • Sanjiban Chakrabarty (Erasmus MC) Breast cancer-on-chip: optimizing models for personalized medicine
  • Pien Goldsteen (RUG) Development of a microfluidic chip for the study of neuro-effector interaction in an airway system
  • Vincent van Duinen (LUMC) Perfused 3D angiogenic sprouting assay in vitro of hiPSC-derived endothelial microvessels
  • Alessandro Juliano (Erasmus MC) Fabrication of a muscle-on-chip using hiPSCs derived myogenic progenitor cells for in vitro studies on skeletal muscle disorders
  • Mees de Graaf, (LUMC/UTwente) A scalable three-dimensional blood vessel-model on chip using human induced pluripotent stem cell-derived vascular cells.
  • Bas Lendemeijer (Erasmus MC) Rapid specification of human pluripotent stem cell derived neural progenitors to functional astrocytes
  • Hossein Eslami Amirabadi (TNO/ UU) Gut on-a-chip: intestinal barrier model to study intestinal absorption
  • Alex Bastiaens (TU/e) Nano- and microengineered neuronal cell networks for brain-on-chip technology

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