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Public Information Day on Biology-inspired Microphysiological Systems (MPS)

Thursday, 4 July

On 17 June 2019 in Berlin (Germany) the Centre of Alternatives to Animal Testing-Europe held its information day on Biology-inspired Microphysiological Systems (MPS) to advance Medicines for Patients Benefit with key international experts from academia, regulatory agencies, and industry. CAAT-Europe coordinates transatlantic activities aimed at promoting new approach methods in toxicology. Microfluidic microphysiological systems - also referred to as tissues or (multi)organ-on-chip - are considered an enabling technology for the development of approaches to reliably predict the safety and efficacy of novel drug candidates prior to their use in humans.

hDMT Managing Director Janny van den Eijnden - van Raaij was one of the keynote speakers, presenting hDMT and networking in Europe.

The public information day took a snapshot of the important aspects of the expert T4 think tank that was held afterwards on Biology-inspired Microphysiological Systems Approaches to Solve the Drug Testing Dilemma.

Program and topics of the information day.

Introduction by the Organizers
Florian Hoos (Centre for Entrepreneurship, Technische Universität Berlin)
Marcel Leist (Centre of Alternatives to Animal Testing -Europe)
Adrian Roth Roche (CAAT MPS workshop Organizer)

Challenges in Predictive Toxicology - what can MPS bring to the table
Thomas Hartung, Johns Hopkins Bloomberg School of Public Health, USA

The NIH Tissue Chips for Drug Screening Program: Current and Future Directions
Danilo A. Tagle, NCATS, National Institute of Health, USA

Highlights of tissue chip models, developed at Wyss Institute
Donald E. Ingber, Wyss Institute for Biologically Inspired Engineering at Harvard, USA

DARPA Integrated 10-Organ System Using a Microwell System
Linda G. Griffith, Massachusetts Institute of Technology, USA

hDMT and Organ-on-Chip networking in Europe
Janny van den Eijnden, human Organ and Disease Model Technologies, The Netherlands

RESTORE - introducing a European Large Scale Research Initiative to accelerate Delivery of Advanced Therapies through MPS Tools
Petra Reinke, Charité, Berlin Center for Advanced Therapies & BIH-Center for Regenerative Therapies (BCRT), Germany

Pharmaceutical Industry Perspective on Organ-on-a-Chip technology
Thomas Singer, Roche Pharmaceuticals, Switzerland

FDA Perspectives on Tissues-on-Chips
Donna Mendrick, Food and Drug Administration, USA

Commercializing integrated Microphysiological Systems: current Status and future Potential
Uwe Marx, TissUse GmbH a spin-off of the Technische Universität Berlin, Germany

GO Bio Transfer at the Centre for Entrepreneurship - creating an environment for numerous TissUse-like spin-offs
Christine Oesterhelt, Centre for Entrepreneurship of Technische Universität Berlin, Germany

Needs meet seeds; updates of user-driven MPS research project in Japan
Takafumi Akabane, Stem Cell Evaluation Technology Research Association, Japan

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