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Grant for research into blood vessels of HHT patients with Organ-on-Chip

Wednesday, 9 October 2019

Prof. Christine Mummery, Dr. Franck Lebrin and Dr. Valeria Orlova, members of the hDMT Vessel-on-Chip Theme Group, together with doctors at St Antonius Hospital in Nieuwegein, receive a grant for research into Rendu Osler Weber's disease. The sum of 500,000 euros comes from ZonMw's Translational Research programme.

The researchers will use mouse models and Organs-on-Chip to study abnormalities in blood vessels of patients with Rendu Osler Weber's disease (also called Hereditary Hemorrhagic Telangiectasia or HHT).

3D Vessels-on-Chip (photo credits: Amy Cochrane)

The project focuses on the study of drugs, both in HHT patients and in blood vessels made from stem cells originating from these patients. A total of five drugs will be tested, all known for their healing effects in other diseases, so-called 'drug repurposing'. The most effective drugs will also be tested in clinical applications with several dozen patients.

Heavy nosebleeds

HHT patients have abnormalities in the blood vessels in their skin, lungs, liver and brain that make them very weak and easy to bleed. HHT patients suffer most from this abnormality in their nose, resulting in heavy nosebleeds several times a day. Inflammations in the nose play a role in this.

Source: LUMC (in Dutch)

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