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TURBO grant for Michel van Putten and Nael Nadif Kasri for Brain-in-a-Dish

Thursday, 19 December 2019

The TURBO programme of the Radboudumc and the University of Twente has awarded Michel van Putten (UTwente) and Nael Nadif Kasri (Radboudumc) for their technical-medical research proposal 'EEG in-a-dish: towards PRecisIoN mediCine for EpilepSy (PRINCES).'

Epilepsy or epileptic seizures give an abnormal electrophysiological picture, visible in an Electro-encephalography (EEG). Drugs are used to suppress the seizures and reduce the disturbed relationship between stimulation and suppression of the neurological networks.

In this project, a Brain-in-a-Dish is cultured from patients with epilepsy via iPS cells. It is expected that the neurologically abnormal patterns (the epilepsy) can also be visualized in such a mini-brain with an EEG. Such an EEG-in-a-Dish can be used, among other things, for drug research, which can shorten the sometimes long search for the right drug. The data may also be valuable for determining drug resistance and considering other treatment options.

TURBO grant enables the research groups to develop an innovative idea that should lead to a follow-up application to an external grant provider.

Foto credits: Nael Nadif Kasri (Radboudumc)

Source: Radboudumc (Dutch)

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