ECR Proof of Concept grant for Albert van den Berg for standardised Organ-on-Chip infrastructure

Friday, 10 January

The European Research Council has awarded hDMT PI Albert van den Berg of the University of Twente, an ERC Proof of Concept grant for furthering standardisation in organ-on-chip infrastructure. Proof of Concept grants, worth €150,000 each, aim to help ERC grantees to explore the innovation potential of their scientific discoveries and bring the results of their frontier research closer to market.

Organ-on-Chips are believed to revolutionise the way we develop drugs or select personalised therapies. Recapitulating human response both from healthy and diseased individuals potentially even enables 'clinical trials in-a-dish'. While research in this field is thriving and commercial start-ups have been founded, adoption from end-users is staying behind for a number of reasons: lack of standardisation makes chips incompatible, lack of automation limits the throughput and user-friendliness of the systems and there is limited support for sensor integration.

The Translational Organ-on-Chip Platform (TOP) is designed to overcome these hurdles and has been developed for internal use during the ERC project VESCEL. The research will work on a robust interconnect, validate and identify difficulties in making a third-party chip TOPcompatible, validate the use of TOP for biological experiments and finally determine the commercialisation strategy for TOP.

Albert van den Berg: "We believe TOP can help more end-users to adopt Organ-on-Chip as a technology in their lab because in contrast to current setups, the open technology of TOP supports chips from third parties are inter-compatible, multiplexable and controlled automatically. TOP will be the standardised Organ-on-Chip infrastructure allowing users to stop worrying about control systems and only focus on chips and biology."

Source: UTwente.

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