News

Andrew Morrison starts on development of immune competent Lymph node-on-Chip model

Saturday, 2 May

Andrew Morrison recently joined the group of hDMT PI Sue Gibbs of the Amsterdam UMC, location VUMC. He is going to work on the Lymph node-on-Chip model project.

This project is in collaboration with the Amsterdam Rheumatology Center for Autoimmune Diseases (ARCAID) in order to develop a functional 3D organotypic lymph node with integrated lymphatics that mimic adaptive immune responses.

Combining research on lymph node stromal cells and current in-house expertise of tissue engineering and microfluidic devices, the overall objective is to design an Organ-on-Chip model that features lymphatic drainage of an immune competent gut into a lymph node, i.e. "Lymph node-on-Chip". The immunosurveillance capability of the potential model will be assessed by inducing an inflammatory response, with the end goal of utilizing this technology for testing of Rheumatoid Arthritis (RA) drugs.

Back to the news overview