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Britt van der Leeden starts development of a Skin-on-Chip with flow

Saturday, 2 May

Britt van der Leeden recently joined the group of hDMT PI Sue Gibbs of the Amsterdam UMC, location VUMC. She is going to work on a Skin-on-Chip with flow, for research on neutrophil extracellular trap formation (NETosis) that drives burn-induced thrombosis and wound deepening.

It is recently found that extensive microvascular thrombosis occurs in and around burn wounds, which persisted for up to weeks after the initial burn injury. In addition, this coincided with neutrophil extracellular traps (NETosis) formation, the process whereby neutrophils eject net-like structures of their DNA. NETosis has been shown to be a major initiator of blood coagulation and microvascular damage. These phenomena can drastically reduce blood flow to the affected skin, contributing to wound deepening and suboptimal healing. NETosis may, therefore, be a promising therapeutic target in order to prevent microvascular thrombosis and wound deepening in burn wound patients.

In collaboration with the Department of Molecular Cell Biology and Immunology, and Pathology of the Amsterdam UMC, the Association of Dutch burn Centres and Pharming, this project aims to unravel the mechanisms underlying burn-induced NETosis and resultant microvascular thrombosis and damage, and how these relate to wound deepening and suboptimal healing, in a skin integrated vascular channel-on-a-chip model, i.e. "Skin-on-Chip with flow". Furthermore, it is studied whether therapeutic inhibition of NETosis can counteract post-burn thrombosis and microvascular damage. This project was the result of a TPI Helpathon (www.tpihelpathon.nl).

For more details about this project: Neutrophil extracellular traps drive burn-induced thrombosis and wound deepening

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