Ahmed Sharaf starts on light-assisted 3D manufacturing of neuronal microenvironments

Friday, 15 May 2020

Ahmed Sharaf recently joined the group of hDMT PI Angelo Accardo, Assistant Professor at Delft University of Technology, Department of Precision and Microsystems Engineering (PME). He is going to work on Light-assisted 3D manufacturing of neuronal microenvironments.

The continuous evolution of additive manufacturing technologies opened a new era for the prototyping of 3D micro- and nanostructured devices. In the field of bioengineering, one of the most fascinating challenges is the creation of biomimetic engineered microenvironments able to reproduce the features that we find in organs of the human body.

A very elegant approach to create polymer/hydrogel structures for cell biology applications is to employ two-photon polymerization (2PP), a fabrication technique allowing to precisely shape biomaterials by using light. In such context, it was recently demonstrated how laser-assisted additive manufactured 3D microenvironments can foster the development of 3D neuronal networks characterized by a multi-technique imaging protocol involving scanning electron microscopy and advanced 3D immunofluorescence imaging.

Within this project, Ahmed will design, fabricate and characterize 3D structures to unveil how topographical and mechanical cues affect neural cell mechanobiology, migration and differentiation. The investigation will be conducted in close collaboration with neural cell biology labs and medical centers such as the Biomedical Primate Research Center (BPRC) and the Leiden University Medical Center (LUMC).

For more details about Accardo's team research on engineered cell microenvironments: Angelo Accardo's Lab

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