Grant for refinement of 3D-Muscle-on-Chip model

Wednesday, 23 September

hDMT PIs Jessica de Greef from LUMC in Leiden, Pim Pijnappel from Erasmus MC and Coen Ottenheijm from Amsterdam UMC, received a grant from Health Holland/Prinses Beatrix Spierfonds to further develop their 3D-Muscle-on-Chip model for research on muscle diseases.

In previous research, a 3D muscle has been developed which is a miniature version of the muscle made out of human skin cells that can move and contract. The muscle can be healthy one or have a muscle disease such as Pompe disease and FSHD. Linked to a chip that measures the movement of the muscle, the Muscle-on-Chip can be used to test medication.

The goal of the current research 'Myofiber and myofibril contractility in hiPSC-derived 3D muscle' is to measure not only the forces of the entire 3D muscle but also of the smallest units of the muscle, the sarcomeres. The grant amounts € 312.000,- and is co-financed with PPP supplement made available by Health~Holland, Top Sector Life Sciences & Health, to the Prinses Beatrix Spierfonds to stimulate public-private partnerships.

Also the Dutch television program '5 Hours Show' paid attention to this Muscle-on-Chip project. (screenshot)

Source: Prinses Beatrix Spierfonds (in Dutch)

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