Nele Revyn start on 3D microelectrode arrays for Brain-on-Chip research
In August 2020, Nele Revyn joined the ECTM group at TU Delft as a PhD student under the supervision of Prof. Lina Sarro and Dr. Massimo Mastrangeli. Her background lies in digital and analog chip design, and her work will feature within the Netherlands Organ-on-Chip Initiative (NOCI).
Revyn's research will encompass the Brain-on-Chip field by creating 3D microelectrode arrays for measuring neural responses. Previous research has enabled readout of neural responses with 2D microelectrode arrays. However, neurons communicate with each other in three dimensions. Therefore, scientists are asking for a platform that enables readout in not only two but three dimensions. The envisioned 3D microelectrode arrays, with electrodes at distinct tissue depths, is the first step to enable that. Over time, the goal is to make the entire structure non-rigid (maybe even soft) so neurons can adhere easily to the electrodes without disturbing the neuronal tissue, and transparent, so opto-electric neural stimulation becomes possible.
"I have always been fascinated by the human brain (I even considered going to medical school!), so being able to contribute to Brain-on-Chip research brings me much enthusiasm," Revyn says.