Grant for OA Gender differences on-Chip
hDMT researcher Liliana Moreira Teixeira Leijten of the University of Twente has received an ENW-KLEIN grant for her research into gendered chips for healthy knees and hips. The grant is awarded by the science financier NWO and consists of about 300.000 euros.
Gendered chips for healthy knees and hips
A multitude of approved drugs and treatments may have negative to no effects on the female population, mainly due to lack of representative studies on diseases impacting both genders differently. Osteoarthritis (OA) is a chronic disease affecting millions worldwide, where gender differences are not yet understood nor considered when developing treatments.
This project proposes a novel approach to understand the gendered nature of OA based on a micro-physiological (male vs. female) model of the human joints, named osteochondral-unit-on-a-chip. This model will contribute to understanding the onset and progression OA, to more effectively develop and screen drugs tailored for each gender.
KLEIN grants are intended for realizing curiosity-driven, fundamental research of high quality and/or scientific urgency. The KLEIN grant offers researchers the possibility to elaborate creative and risky ideas and to realize scientific innovations that can form the basis for the research themes of the future.