Eurostars project of 1.4 million for development of compact Organ-on-Chip system
A consortium of hDMT partner Leiden University Medical Center (LUMC) together with Bi/ond and Fluigent have received 1.4 million euros via the European EUROSTARS program for a new Organ-on-Chip system that mimics the physiological conditions of the human body.
The two companies will deliver the very first compact Organ-on-Chip system that can keep complex 3D models alive - via a vascularized channel, including microfluidic flow - and at the same time provide mechanical stimulation. LUMC will qualify the system for 3D cardiac tissue models based on cardiomyocytes from human induced pluripotent stem cells.
"We want to radically improve the quality of research on 3D tissues models by developing a compact Organ-on-Chip solution combining organ-vessel interaction and ease of use. We are delighted to run this project with LUMC and Fluigent", said Dr Cinzia Silvestri, CEO and co-founder of Bi/ond.
This innovative solution will save biologists time and costs, it is compact and will be usable with minimal training. Presently, this type of study is limited by the short time that 3D tissues cultured in vitro are viable.
"The system that will emerge from this project will allow us to keep our complex 3D models in culture for longer periods of time. This is not just an incremental improvement but it will allow us to explore new types of biological questions such as what happens to the heart during long-term exposure to drugs used for example in chemotherapy", said Berend van Meer, researcher and project coordinator of the LUMC.
The 1.4 million euro CompactOoC-3D project has been funded by the EU under the EUROSTARS program. EUROSTARS supports the development of innovative products that impact people`s lives around the world. The grant has joint contributions from the Netherlands Enterprise Agency (RVO) and Bpifrance.