TURBO Grant for Metabolic Fitness of the heart
In a collaborative pilot project between the hDMT partners Twente University and Radboudumc, Robert Passier (Universtity of Twente, on the left) and Dirk Lefeber (Radboudumc, on the right) will investigate the metabolism of sugars and other pathways of central carbon metabolism in 2D cardiomyocytes and 3D engineered heart tissue in Heart-on-Chip models.
Cardiovascular disease is the leading cause of mortality and morbidity worldwide and is expected to increase to epidemic proportions. It has become increasingly clear that metabolism plays an important role in heart function in health and disease.
Patients with PGM1-myopathy, a genetic defect in sugar metabolism and energy production, suffer from heart failure. Protocols for steady-state and dynamic analysis of these metabolic pathways will be applied to patient-derived induced pluripotent stem cells and their differentiated cardiac models to test several rationale treatment strategies.
The grant is part of the TURBO program, a collaboration between the University of Twente (TechMed Centre) and the Radboudumc. With the grant, research groups from both institutions can further develop an innovative idea with the intent of subsequently submitting it to an external grant provider. The TURBO program is now in its fourth year.