Two stemcell projects granted by ZonMw
ZonMw granted two projects by hDMT researchers.
1. Human stem cell-based high-throughput screening platform for cardiac disease
Goal: In this research project we will use a human pluripotent
stem-cell based heart on chip model where we measure important
functional parameters of cardiomyocytes, such as contractility,
electrophysiology and calcium signalling in a high throughput
system. This will allow us to develop better and safer drugs and
reduce the number of animals.
ZonMw Programme 'Toepassen van Innovaties'
University of Twente
Main applicant: Prof.dr. R. Passier
co-applicant: Prof.dr. D. Stamatialis
co-applicant: Dr. A. van der Meer
Main Researchers Marcelo Ribeiro and Iris Allijn
2. Diseased cardiomyocytes from human stem cells for drug-repurposing and safety pharmacology
Goal: applying hiPSC-CMs and integrated electrophysiological
technology in identifying compounds to treat long-QT syndrome) and
to implement this disease hiPSC-CM platform in drug development
(e.g. anti-arrhythmic) and drug safety testing (e.g. pro-arrhythmic
prediction) directly into the FDA/EMA drug development and approval
ZonMw programme 'Meer Kennis met Minder Dieren'
Leiden University Medical Center
Main applicant: Prof. C. Mummery
Projectleader: Dr. M. Bellin
Main researcher: Dr. L. Sala
Leiden Academic Centre for Drug Research
Co-projectleader: Prof. A. IJzerman
Contact person: Dr. S. Braam