KWF/Alpe d'HuZes grant for cancer on chip
An hDMT team led by researcher Dik van Gent (Erasmus MC) has received a grant from the Dutch Cancer Foundation (KWF) and financed by the Alpe d'HuZes funding scheme. The project team will develop a cancer-on-chip device that allows relatively long term culturing of (breast) tumor tissue.
The project aims to develop and optimize technology to grow breast tumor tissue in a microfluidics set up. Schematic representation of the Cancer-on-Chip prototype to be developed in this project. Single Cancer-on-Chip (a-c) and Chip holder in 6-well microtiter format with double flow microfluidic system (d,e) . Shown is the intended set up of the culture method. (Credit: Nikolas Gaio and William Quiros Solano).
Title: Developing a validated Cancer-on-Chip prototype for personalized medicine
Description: Cancer is a very heterogeneous disease: many different types of tumors exist and even not all tumor cells in one tumor are the same. This is a big problem for clinical decision making. How should we treat each individual tumor and how exactly does the tumor react to such a treatment? These questions are difficult to address when the tumor is still inside the body, but could be answered more readily if we can grow the tissue outside the body, where we can image the tissue using microscopic techniques. Therefore, we aim to develop the technology to make this possible. The project brings together (medical) biologists, engineers and the company Genmab, who will work together on creating a working and validated 'cancer-on-chip' prototype that can be used in future projects for personalized medicine, as well as for asking fundamental questions about cancer biology. The project is unique in bringing together these expertises and it is high risk, because it is difficult to predict what the optimal technological set up will be. However, the options for further research will be enormous if the project teams succeed in its endeavor.
PI: Dr. Dik van Gent, Department of Molecular Genetics, Erasmus MC
Academic partners: Prof. dr. Jaap den Toonder (Department of Mechanical Engineering, TU Eindhoven); Dr. Erik Danen (Leiden Academic Center for Drug Research (LACDR), Leiden University), Prof. Dr. Ronald Dekker (Department of Microelectronics, TU Delft), Prof. Dr. Jos Jonkers (Department of Molecular Pathology, Netherlands Cancer Institute) and Dr. John Martens (Department of Medical Oncology, Erasmus MC)
Private partner: Genmab
Project duration: 18 months
Project funding: € 170,420