TURBO grant for Roland Brock and Séverine Le Gac for Tumor-on-Chip research
In the second round of Twente University Radboudumc Opportunities (TURBO) grants Roland Brock (Radboudumc) and Séverine Le Gac (UT) were awarded for their new technical-medical research proposal on a smart Tumor-on-Chip.
Hypoxia (oxygen deficiency)
in a tumor increases the aggressiveness and hinders the
effectiveness of immunotherapy. Currently, no therapy exists that
specifically targets hypoxic cells in tumors. Conversely, for the
development of such therapeutics, appropriate in vitro models are
needed that recapitulate the tumor microenvironment and the tumor
oxygenation conditions as close as possible. In that context, a
smart tumor-on-a-chip platform will be developed that mimics
essential features of the complex hypoxic tumor microenvironment,
and incorporates embedded sensors for real-time monitoring of the
oxygen concentration, cell metabolism, and pH. In parallel, novel
hypoxia-specific therapeutic treatments will be developed and
evaluated using the proposed smart tumor-on-a-chip platform.
This research will be conducted by experts in microfluidics and sensing (UT) and drug targeting and oncology (Radboudumc).
With the TURBO grant the researchers can further develop their innovative idea with the intent to acquire a larger external grant provided by national and European funds and companies that are active in the field of health care and technology.
photo credit: Jean-Baptiste Blondé