News

BIORIMA (Biomaterial Risk Management) aims to develop an integrated risk management framework for nanobiomaterials used in Advanced Therapeutic Medicinal Products and Medical Devices. The BIORIMA risk management framework is a structure upon which the validated tools and methods for materials, exposure, hazard and risk... Read more

A joint project proposal of researchers from Maastricht University (UM) and Maastricht University Medical Center (MUMC) on novel 3D organ-on-a-chip technology has recently been granted by MUMC+ with 250,000 €. The kick-off of this project was 1 September. In a collaborative effort, the two teams of Prof. Coen Stehouwer, Prof. Casper... Read more

Call to unite stakeholders and experts Leiden University Medical Center and the Dutch Organ-on-Chip consortium hDMT are now leading an EU initiative that will establish a European infrastructure to enable coordinated development, production and implementation of Organs-on-Chips by a consortium of academic and private partners. In... Read more

A team led by hDMT scientist Christine Mummery (LUMC) has received a TKI-PPS grant of 180.000 Euro from Stichting Life Sciences Health for the development of a drug screening platform based on cardiomyocytes from hiPS cells of patients with the genetic heart disease CPVT. The research on the development of clinically relevant... Read more

Luc Sala et al published a software tool that can be used to measure cell contractions. NB: This tool was also presented at the Interactive Masterclass with Kit Parker, 12 September 2017 in Amsterdam. Contraction of muscle reflects its physiological state. Methods to quantify contraction are often complex, expensive and tailored to... Read more

The LUMC has granted the iPSC core facility extra finance to support the development of an "iPS cell Hotel". In a start up phase, 2 new postdocs and a technician will be trained to support training in the use of human induced pluripotent stem cells and the co-development of new differentiation protocols and gene modification... Read more

Researchers from MERLN Institute for Technology-Inspired Regenerative Medicine hosted a symposium dedicated to the subject "Microfactories for Tissue Engineering or Regeneration on a Chip" at the European Chapter Meeting of the Tissue Engineering and Regenerative Medicine International Society 2017 (TERMIS-EU 2017), in Davos,... Read more

Dr. Paul Wieringa, researcher at the Department of Complex Tissue Engineering from MERLN / Maastricht University has been awarded with the prestigious Veni grant, from Netherlands Organisation for Scientific Research (NWO). This grant accounting for 250.000 euros, will allow this MERLN junior researcher to setup his innovative project... Read more

LOCATE: Integrated platform to design novel cancer localization strategies by ultrasound microvasculature imaging A team led by hDMT scientist Jaap den Toonder (TU/e) has received a grant from NWO-TTW (total 1 Million Euro, 3 PhD students) to develop a novel experimental platform that enables to understand and develop ultrasound imaging... Read more

PESCADoR: PhEnotypic Screening for CAncer DRug Discovery hDMT scientist Jaap den Toonder (TU/e) participates in a consortium that has obtained funding from the Academy of Finland (total 990 kEuro) to develop an experimental platform that recapitulates the architecture of human cancers for testing anti-cancer therapies as well as means... Read more

Jean-Philippe Frimat (postdoc in the microsystem group at TU/eindhoven) has been awarded an Off Road grant (125.000 Euro) by ZonMW for his proposal on developing a Human brain biopsy on a chip. The purpose of the Off Road grants is to enable young biomedical researchers to achieve breakthroughs by doing out-of-the-box... Read more

A team of PhD candidates Cinzia Silvestri, William Quiros Solano and Nikolas Gaio (start-up company BI/OND ) and Ronald Dekker (TU/e) have recieved an NWO Take-Off Grant (Phase 1) for organ-on-a-chip development. NWO Take-off focuses on facilitating and encouraging commercial and entrepreneurial activities... Read more

An hDMT team led by researcher Dik van Gent (Erasmus MC) has received a grant from the Dutch Cancer Foundation (KWF) and financed by the Alpe d'HuZes funding scheme. The project team will develop a cancer-on-chip device that allows relatively long term culturing of (breast) tumor tissue. Project information Title:... Read more

hDMT is on the Science shortlist for the Lush Prize 2017. The prize is for individuals, research teams or institutions for work conducted on relevant toxicity pathways. Outstanding research producing an effective non-animal safety test based on an approach other than toxicity pathways, where none existed before, may also be considered. ... Read more

Health~Holland, Top Sector Life Sciences & Health (LSH), launched the Knowledge and Innovation Agenda 2018-2021 titled Grow~Motion. This new strategic document describes the health and care ambitions for the next four years (2018-2021) in the Neterlands. hDMT is mentioned as one of the 18 mature (and thus operational) strategic... Read more

6 minute video, in Dutch Read more

DMD2017 is open for abstract submission. The venue of the conference this year is the High Tech Campus in Eindhoven the Netherlands. Topics include: Organ-on-Chip, Electroceuticals, Clinical Robotics, Smart catheter for cardiovascular interventions, Handheld diagnostics, Smart body patches, In-body / minimally invasive instrument... Read more

Encouraged by the Dutch Enterprise Agency (RVO) representatives of the Mizuho Information & Research Institute in Tokyo visited hDMT at UTwente in Enschede on 18 January 2017. In commission of the Japanese NIH (AMED; Japanese Agency for Medical Research and Development), with involvement of the Japanese Ministry of Econcomy, Trade and... Read more

Lenie van den Broek (VU University Medical Center, Amsterdam) received the Best Poster Award for the presentation of the poster on skin-on-chip during the International Organ-On-Chip Symposium 2017 at the EPFL Campus in Lausanne. Title poster: Skin-on-Chip: Integrating Skin-Tissue and Microsystems engineering. Authors:... Read more

On 2 and 3 May, 2017 the 2nd hDMT International Organ-on-Chip Symposium took place at the EPFL campus in Lausanne. There were 120 participants from various countries and organizations, including universities, knowledge institutes and industry. Over 30 posters were presented and there... Read more

hDMT researchers publish article in Science on safer drug testing using human cellular models hDMT researchers co-authored an article in Science on the effects of the chemical BIA1 10-2474 on human nerve cells. In 2016 in a clinical trial with this drug in Rennes, France, serious adverse events occurred affecting five participants, including... Read more

hDMT researchers receive NWO Gravitation grant for 10 years of top level, curiosity-driven, scientific research The six NOCI PI's at the granting ceremony. From left to right: Hans Clevers, Christine Mummery (project leader), Lina Sarro, Jet Bussemaker (Minister of Health), Michel Ferrari, Albert van den Berg, and Sebo... Read more

The American Food and Drug Administration (FDA) announced a multi-year research and development agreement with a company called Emulate Inc. to evaluate the company's "Organs-on-Chips" technology in laboratories at the agency's Center for Food Safety and Applied Nutrition, one of a number of FDA efforts to help... Read more

The first VU Campus - hDMT meeting was organized at 21th of March to introduce hDMT research to the VU Campus and to present the several human organ and disease model technologies which are currently developed on the VU Campus. Speakers Sue Gibbs started with a presentation to introduce hDMT.In the second part of the program several VU... Read more

Development published a special issue on organoids. Hans Clevers and Jarno Drost published an article in this issue: Translational applications of adult stem cell-derived organoids This special issue features original research articles on organoids representing a range of different organs, including the brain,... Read more