On July 11th, 2016 the hDMT Brain-on-chip group has officially kicked-off with a meeting of partners at ErasmusMC in Rotterdam. The expertise, skills and facilities in the area of brain-on-chip research of the hDMT partner organizations were presented and shared and inspired existing and potential collaborations. 

Program coordinators

Nael Nadif Kasri
Radboud UMC

Massimo Mastrangeli 
TU Delft

Upcoming meeting

  • 12 April (10-16h, TU Delft)
  • 11 October (10-16h, Amsterdam UMC)

Previous meetings

  • 1 November 2023 (Radboudumc)
  • 6 April 2023 (Erasmus MC)
  • 12 October 2022, Delft (TU Delft)
  • 4 March 2022
  • 4 March 2021, Online (10-13h)
  • 28 January 2021, Online (13-16h)
  • 13 May 2020, Nijmegen (cancelled)
  • 27 September 2019, Groningen (host UMCG)
  • 10 January 2019, Delft (host TUDelft)


Shriya Rangaswamy joined NOCI for Brain-on-Chip research

Shriya Rangaswamy started her PhD with the Electronic Components, Technology and Materials (ECTM) Department at TU Delft from October, 2021. She received her Master’s degree in Biomedical Engineering from TU Delft in March, 2021. She collaborated with BI/OND Solutions as a part of her Master Thesis, where she focused on developing...

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Bastiaens, A., Xie, S., & Luttge, R. (2019). Nanogroove-enhanced hydrogel scaffolds for 3D neuronal cell culture: an easy access brain-on-chip model. Micromachines10(10), [638]. https://doi.org/10.3390/mi10100638

Bastiaens, A., Frimat, J. P., van Nunen, T., & Luttge, R. (2019). Exploiting nanogroove-induced cell culture anisotropy to advance in vitro brain models. Journal of Vacuum Science and Technology B: Nanotechnology and Microelectronics37(6), [061802]. https://doi.org/10.1116/1.5119687

Frega, M., Linda, K., Keller, J.M. et al. Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling. Nature Communications 10, 4928 (2019) doi:10.1038/s41467-019-12947-3

Sijia Xie, Bart Schurink, and Erwin J. W. Berenschot, Roald M. Tiggelaar, Han J. G. E. Gardeniers, Regina Luttge “Displacement Talbot lithography nanopatterned microsieve array for directional neuronal network formation in brain-on-chip” (2016) AVS Journal of Vacuum Science & Technology B, Nanotechnology and Microelectronics: Materials, Processing, Measurement, and Phenomena, DOI http://dx.doi.org/10.1116/1.4961591


Fedorovich S, Hofmeijer J, van Putten MJAM, and le Feber J. Reduced synaptic vesicle recycling during hypoxia in cultured cortical neurons. Front Cell Neurosci accepted for publication, 2017.
Hofmeijer J, Mulder ATB, Farinha AC, vanPutten MJAM, and le Feber J. Mild hypoxia affects synaptic connectivity incultured neuronal networks. Brain Res 1557: 180-189, 2014.

Le Feber J, Postma W, de Weerd E, Weusthof M, and Rutten WLC. Barbed channels enhance unidirectional connectivity between neuronal networks cultured on multi electrode arrays. Front Neurosci 9: 412, 2015.

Le Feber J, Stoyanova II, and Chiappalone M. Connectivity, excitability and activity patterns in neuronal networks. Phys Biol 11: 036005, 2014.

le Feber J, Tzafi Pavlidou S, Erkamp N, van Putten MJAM, and Hofmeijer J. Progression of Neuronal Damage in an In Vitro Model of the Ischemic Penumbra.PLoS One 11: e0147231, 2016.

le Feber J, Witteveen T, van Veenendaal TM, and Dijkstra J. Repeated stimulation of cultured networks of rat cortical neurons induces parallel memory traces.Learning & Memory 22: 594-603, 2015.

Raiss CC, Braun TS, Konings IBM, Grabmayr H, Hassink GC, Sidhu A, le Feber J, Bausch AR, Jansen C, Subramaniam V, and Claessens MMAE. Functionally different α-synuclein inclusions yield insight into Parkinson’s disease pathology. Scientific Reports 6: 23116, 2016.

Stoyanova I, Hofmeijer J, van Putten MAM, and le Feber J. Acyl Ghrelin Improves Synapse Recovery in an In Vitro Model of Postanoxic Encephalopathy.Molecular Neurobiology 1-8, 2015.

Stoyanova II, and Le Feber J. Ghrelin accelerates synapse formation and activity development in cultured cortical networks. BMC Neurosci 15: 49-, 2014.

Fedorovich S, Hofmeijer J, van Putten MJAM, and le Feber J. Reduced synaptic vesicle recycling during hypoxia in cultured cortical neurons. Front Cell Neurosci accepted for publication, 2017.