The hDMT Gut-Liver-on-Chip theme group focusses on advanced human inspired in vitro models that adequately mimic the functionality of the gastrointestinal tract and the functionally tightly coupled liver in order to study physiological processes in and between these organs, drug and nutrient handling and related human diseases.

The Gut-Liver-on-Chip (GLoC) theme group is a joint hDMT and NOCI initiative.

Program coordinators

Upcoming meeting

  • 18 March 2022
  • 29 September 2022

Previous meetings

  • 5 February 2021, Online (10-13h)
  • 9 October 2019, Amersfoort
  • 24 January 2019, Wageningen (host WUR)

News

Research theme challenges

A Gut-on-Chip and a Liver-on-Chip, or the combination of both model systems on an integrated platform requires a careful considerations of the minimal organ functionality that needs to be emulated in vitro. For several reasons innovative experimental models are needed, for instance to:

  • understand the course of intestinal and liver diseases
    Better understand the natural course of both intestinal and liver diseases. For instance celiac disease, Crohn disease and other inflammatory bowel diseases. Inflammatory liver diseases that include fibrotic processes are still not fully understood, and clearly lack robust human like in vitro models, hindering our current understanding of the onset and mechanisms of disease.
  • predict human responses to xenobiotics
    Innovative toxicological research aims to reveal mechanism of adverse reactions, also termed adverse outcome pathways. To adequately predict human responses to xenobiotics it is key to find the balance between highly standardized experimental models (with limited between laboratory variability) and human organ functioning.

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Publications

Cayetano Pleguezuelos-Manzano, Jens Puschhof, […] Hans Clevers (2020) Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. Nature 580, 269–273.

Renée Moerkens, Joram Mooiweer, Sebo Withoff  and Cisca Wijmenga (2019) Celiac disease-on-chip: Modeling a multifactorial disease in vitro, United European Gastroenterology Journal.

Marwah Doestzada, Arnau Vich Vila, Alexandra Zhernakova, Debby P. Y. Koonen, Rinse K. Weersma, Daan J. Touw, Folkert Kuipers, Cisca Wijmenga, Jingyuan Fu (2018) Pharmacomicrobiomics: a novel route towards personalized medicine? Protein Cell , 9(5):432–445,

Gilles S. van Tienderen et al. (2019) Review. Recreating Tumour Complexity in a Dish: Organoid Models to Study Liver Cancer Cells and their Extracellular Environment, Cancers (Basel). Nov 1; 11(11). pii: E1706. doi: 10.3390/cancers11111706.

Hötte K, et al. Ultra-thin fluorocarbon foils optimise multiscale imaging of three-dimensional native and optically cleared specimens. Sci Rep. 2019 Nov 21; 9(1):17292. doi: 10.1038/s41598-019-53380-2.

Vicent S, et al.  Experimental models to unravel the molecular pathogenesis, cell of origin and stem cell properties of cholangiocarcinoma. Liver Int. 2019 May; 39 Suppl 1:79-97. doi: 10.1111/liv.14094. Review.