A Gut-on-Chip and a Liver-on-Chip, or the combination of both model systems on an integrated platform requires a careful considerations of the minimal organ functionality that needs to be emulated in vitro. For several reasons innovative experimental models are needed, for instance to:
- understand the course of intestinal and liver diseases
Better understand the natural course of both intestinal and liver diseases. For instance celiac disease, Crohn disease and other inflammatory bowel diseases. Inflammatory liver diseases that include fibrotic processes are still not fully understood, and clearly lack robust human like in vitro models, hindering our current understanding of the onset and mechanisms of disease.
- predict human responses to xenobiotics
Innovative toxicological research aims to reveal mechanism of adverse reactions, also termed adverse outcome pathways. To adequately predict human responses to xenobiotics it is key to find the balance between highly standardized experimental models (with limited between laboratory variability) and human organ functioning.