Peer-reviewed publications of hDMT researchers about topics related to Microphysiological Systems and Organ-on-Chip technology are listed below.

Information about research topics of PhD students who graduated within the hDMT partner organizations is available via the button ‘PhD theses’.

For publications with a broader scope, including review papers, showcases, regulatory aspects, workshop reports, whitepapers etc, from researchers within hDMT or beyond, please scroll through the list of ‘Core publications’.

2022

Nastaran Barin, et al. (2022)  3D-Engineered Scaffolds to Study Microtubes and Localization of Epidermal Growth Factor Receptor in Patient-Derived Glioma Cells, Small (Wiley online library)

Swati Sharma*,et al. ( 2022) Testis-on-chip,platform to study ex vivo primate spermatogenesis and endocrine dynamics, (Organs-on-a-Chip).

Stein JM, et al. (2022).  Software Tool for Automatic Quantification of Sarcomere Length and Organization in Fixed and Live 2D and 3D Muscle Cell Cultures In Vitro. (Curr Protoc)

Sanne G.S., et al. (2022), An integrated toolbox to profile macrophage immunometabolism,(Cell Reports Methods 2)

Stefanie Fuchs, et al. (2022). On-chip analysis of glycolysis and mitochondrial respiration in human induced pluripotent stem cells. (Materials Today Bio 17) 

Sharaf, A. et al. (2022) Two-photon polymerization of 2.5D and 3D microstructures fostering a ramified resting phenotype in primary microglia (Bioengineering and Biotechnology (IF 5.9)

Saberi, A. et al. (2022) In-vitro engineered human cerebral tissues mimic pathological circuit disturbances in 3D (Nature Communications Biology)

Wissing, T.B. et al. (2022) Tissue-engineered collagenous fibrous cap model to systematically elucidate atherosclerotic plaque rupture (Scientific Reports)

Özkayar, G. et al. (2022) Toward a modular, integrated, miniaturized, and portable microfluidic flow control architecture for organs-on-chips applications (Biomicrofluidics)

Koning, J.J. et al. (2022) A Multi-Organ-on-Chip Approach to Investigate How Oral Exposure to Metals Can Cause Systemic Toxicity Leading to Langerhans Cell Activation in Skin (Frontiers Toxicology)

Paggi, C.A. et al. 2022) Emulating the chondrocyte microenvironment using multi-directional mechanical stimulation in a cartilage-on-chip model (Lab on a Chip)

Palacio-Castadeña, V. et al. (2022) Oxygen control: the often overlooked but essential piece to create better in vitro systems (Lab on a Chip)

Arslan, U et al. (2022) Microphysiological stem cell models of the human heart (Mater Today Bio)

Ramovs V, et al. (2022) Characterization of the epidermal-dermal junction in hiPSC-derived skin organoids(Stem Cell Reports)

Arslan, U et al. (2022)Perspectives for Future Use of Cardiac Microtissues from Human Pluripotent Stem Cells. (ACS Biomater Sci Eng)

Shukla, P. et al. (2022) Mimicking tumor microenvironment by 3D bioprinting: 3D cancer modeling (Biofabrication)

Yiangou, L et al. (2022) Optogenetic reporters delivered as mRNA facilitate repeatable action potential and calcium handling assessment in human iPSC-derived cardiomyocytes. (Stem Cells)

Campostrini, G et al. (2022) Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia.(Cardiovasc Res)

Heinrich, M.A. et al. (2022) Impact of endotoxins on bioengineered tissues and models. (Trends Biotechnol.)

Tuerlings, M. Et al. (2022) Capturing Essential Physiological Aspects of Interacting Cartilage and Bone Tissue with Osteoarthritis Pathophysiology: A Human Osteochondral Unit-on-a-Chip Model (Advanced Materials Technologies)

ul Islam, T. Et al. (2022) Microscopic artificial cilia – a review. (Lab on a Chip)

Chen, P. Et al. (2022) Acoustic characterization of tissue-mimicking materials for ultrasound perfusion imaging research (Ultrasound in Medicine and Biology)

Zhou, G. et al. (2022) Modelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and effector T cells (British J. of Cancer)

Roos, F.J.M. et al. (2022) Human branching cholangiocyte organoids recapitulate bile duct formation (Cell Stem Cell)e organoids recapitulate functional bile duct formation

Stroulios, G. et al. (2022) Apical-out airway organoids as a platform for studying viral infections and screening for antiviral drugs (Nature Scientific Reports)

Wang, L. et al. (2022) Recapitulating lipid accumulation and related metabolic dysregulation in human liver-derived organoids (J. Mol. Med.)

Leung, C.M. et al. (2022) A guide to the organ-on-a-chip (Nature Reviews Methods Primers)

 

2021

Akowala, Q. et al. (2021) Evaluation of Proton-Induced DNA Damage in 3D-Engineered Glioblastoma Microenvironments (ACS Applied Materials & Interfaces (IF 9.2))

Pednekar, K.P. et al. (2021) Novel 3D µtissues Mimicking the Fibrotic Stroma in Pancreatic Cancer to Study Cellular Interactions and Stroma-Modulating Therapeutics. (Cancers (Basel)

Babi et al. (2021) Tuning the Nanotopography and Chemical Functionality of 3D Printed Scaffolds through Cellulose Nanocrystal Coatings (ACS Applied Biomaterials)

Bauer, L et al. (2021) Replication Kinetics, Cell Tropism, and Associated Immune Responses in SARS-CoV-2- and H5N1 Virus-Infected Human Induced Pluripotent Stem Cell-Derived Neural Models (mSphere)

De Jong, J.O. et al. (2021) Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder (Nature Communications)

Chakrabarty, S. et al. (2021)  A microfluidic cancer-on-chip platform predicts drug response using organotypic tumor slice culture (Cancer Res)

Van Hemelryk, A. Et al. (2021) Modeling Prostate Cancer Treatment Responses in the Organoid Era: 3D Environment Impacts Drug Testing (Biomolecules)

Palacio-Castaňeda, V. et al. (2021) Mimicking the Biology of Engineered Protein and mRNA Nanoparticle Delivery Using a Versatile Microfluidic Platform (Pharmaceutics)

Vollertsen, A.R. et al. (2021) Facilitating implementation of organs-on-chips by open platform technology (Biomicrofluidics)

De Haan, P. et al. (2021) A versatile, compartmentalised gut-on-a-chip system for pharmacological and toxicological analyses (Scientific Reports)

Orlova, V. et al. (2021) Heart defects recapitulated in human cardioids. (Cell Res.) 

Rodríguez Ruiz A et al. (2021) Cartilage from human-induced pluripotent stem cells: comparison with neo-cartilage from chondrocytes and bone marrow mesenchymal stromal cells.

Wagstaff, P. et al. (2021) An alternative approach to produce versatile retinal organoids with accelerated ganglion cell development (Scientific Reports)

Brinks, J. et al. (2021) Exploring the choroidal vascular labyrinth and its molecular and structural roles in health and disease (Progress in Retinal and Eye Research)

Brinks, J. et al. (2021) The Cortisol Response of Male and Female Choroidal Endothelial Cells: Implications for Central Serous Chorioretinopathy (J Clin Endocrinology & Metabolism)

Wagstaff, P. et al. (2021) An alternative approach to produce versatile retinal organoids with accelerated ganglion cell development. Scientific Reports volume 11, Article number: 1101 (PMID: 33441707)

Bogunovic, N. et al. (2021) Patient-Specific 3-Dimensional Model of Smooth Muscle Cell and Extracellular Matrix Dysfunction for the Study of Aortic Aneurysms (Journal of Endovascular Therapy)

Venzac et al. (2021) PDMS curing inhibition on 3D printed-molds: Why? And, how to avoid it? (Analytical Chemistry)

Beekman, P. et al. (2021) Organosilicon uptake by biological membranes (Communications Biology)

Giordano L et al. (2021) Review: Microphysiological Systems to Recapitulate the Gut-Kidney Axis (Trends in Biotechnology)

Heinrich, M.A. et al. (2021) Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models (Advanced Drug Delivery Reviews)

Picollet-D’hahan, N. at al. (2021) Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication: Trends in Biotechnology (cell.com) (Trends in Biotech) 

2020

Tang H, et al. (2020) Human Organs-on-Chips for Virology Trends Microbiol

Stein JM. et al (2020) Engineered models of the human heart: Directions and challenges. Stem Cell Reports

Buikema, J. et al. (2020) Wnt signaling and removal of cell-cell contact synergistically induce massive expansion of functional human iPSC-cardiomyocytes (Cell Stem Cell)

Maas, R. et al. (2020) Massive expansion and cryopreservation of beating induced pluripotent stem cell-derived cardiomyocytes (Star protocols)

Maas, R. et al. (2020) Massive expansion and cryopreservation of beating induced pluripotent stem cell-derived cardiomyocytes (Star protocols)

Buikema, J.W. et al. (2020) Wnt signaling and removal of cell-cell contact synergistically induce massive expansion of functional human iPSC-cardiomyocytes. (Cell Stem Cell)

Akiva, A et al. (2020) An Organoid for Woven Bone (Wiley Online Library)

Juni, R.P. et al. (2020) Empagliflozin restores chronic kidney disease-induced impairment of endothelial regulation of cardiomyocyte relaxation and contraction (Kidney International)

Rodrigues, J et al. (2020) 3D In Vitro Model (R)evolution: Unveiling Tumor-Stroma Interactions Trends in Cancer

Van Duinen, V. et al. (2020) Robust and Scalable Angiogenesis Assay of Perfused 3D Human iPSC-Derived Endothelium for Anti-Angiogenic Drug Screening (MDPI)

Junaid, A. et al. (2020) Metabolic response of blood vessels to TNFa, eLife 

 Low, L. et al. (2020) Organs-on-chips: into the next decade (Nature Reviews Drug Discovery)

Liu J. et al. (2020) Cancer-associated fibroblasts provide a stromal niche for liver cancer organoids that confers trophic effects and therapy resistance. Cell Mol 

Chen, S. et al.(2020) Rotavirus Infection and Cytopathogenesis in Human Biliary Organoids Potentially Recapitulate Biliary Atresia Development (mBio) 

Kunst, RF. et l. (2020) From fatty hepatocytes to impaired bile flow: Matching model systems for liver biology and disease (Biochem Pharmacol) 

Krüger, M. et al. (2020). Cellulose Nanofibril Hydrogel Promotes Hepatic Differentiation of Human Liver Organoids (Adv Healthc Mater) .

Umber Saleem, U. et al. (2020) Blinded, multi-centre evaluation of drug-induced changes in contractility using human induced pluripotent stem cell-derived cardiomyocytes (Toxicological Sciences)

Zhang, S. et al. (2020) Metachronal actuation of microscopic magnetic artificial cilia generates strong microfluidic pumping (Lab Chip)    

Zhang, S. et al. (2020) Controlled multidirectional particle transportation by magnetic artificial cilia. (ACS Nano). 

Pilz da Cunha, M. et al. (2020) An artificial aquatic polyp that wirelessly attracts, grasps, and releases objects. (PNAS)

Zhang, S. et al. (2020) Anti-Biofouling and Self-Cleaning Surfaces Featured with Magnetic Artificial Cilia. (ACS Appl. Mater. Interfaces)  

Pilz da Cunha, M. et al. (2020) A soft transporter robot fueled by light. (Advanced Science)

Iuliano, A. et al. (2020) Coupling 3D Printing and Novel Replica Molding for In House Fabrication of Skeletal Muscle Tissue Engineering Devices, (Advanced Materials Technologies)

Dostanić, M. et al. (2020) A Miniaturized EHT Platform for Accurate Measurements of Tissue Contractile Properties, (Journal of Microelectromechanical Systems)

Mart Lamers, M. et al. (2020) SARS-CoV-2 productively Infects Human Gut Enterocytes. (Science)

Si,L. et al.(2020) Human organs-on-chips as tools for repurposing approved drugs as potential influenza and COVID-19 therapeutics in viral pandemics. (bioRXiv.org) 

Junaid, A. et al. (2020) Ebola Hemorrhagic Shock Syndrome-on-a-Chip. (iScience) 

Paggi, C. et al.(2020) Monolithic microfluidic platform for exerting gradients of compression on cell-laden hydrogels, and application to a model of the articular cartilage. (Sensors and Actuators B)

De Almeida Monteiro Melo Ferraz, M. et al. (2020) A dog oviduct-on-a-chip model of serous tubal intraepithelial carcinoma. (Scientific Reports)

De Almeida Monteiro Melo Ferraz, M. et al. (2020) 3D printed mold leachates in PDMS microfluidic devices. (Scientific Reports)

2019

Garrett Ainslie, Myrtle Davis, […] and Anne Ryan (2019) Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: a biopharmaceutical perspective, Lab on a Chip, 19, 3152-3161.

Frans Schutgens, Maarten Rookmaaker, […] and Hans Clevers, (2019) Tubuloids derived from human adult kidney and urine for personalized disease modelingNature Biotechnology 37, 303–313.

Floris van den Brink, Thas Phisonkunkasem, […] and  Mathieu Odijk (2019) A miniaturized push–pull-perfusion probe for few-second sampling of neurotransmitters in the mouse brain, Lab on a Chip 19, 1332-1343.

Zhang, S., Wang, Y., Onck, P. R., & den Toonder, J. M. J. (2019). Removal of microparticles by ciliated surfaces: an experimental study. Advanced Functional Materials, 29(6), [1806434].

Buskermolen, A. B. C., Suresh, H., Shishvan, S. S., Vigliotti, A., DeSimone, A., Kurniawan, N. A., … Deshpande, V. S. (2019). Entropic forces drive cellular contact guidance. Biophysical Journal.

van Kelle, M. A. J., Khalil, N., Foolen, J., Loerakker, S., & Bouten, C. V. C. (2019). Increased cell traction-induced prestress in dynamically cultured microtissues. Frontiers in Bioengineering and Biotechnology, 7, [41].

Wissing, T. B., Bonito, V., van Haaften, E. E., van Doeselaar, M., Brugmans, M. M. C. P., Janssen, H. M., … Smits, A. I. P. M. (2019). Macrophage-driven biomaterial degradation depends on scaffold microarchitecture. Frontiers in Bioengineering and Biotechnology, 7(APR), [87]. DOI: 10.3389/fbioe.2019.00087

Marinke W. van der Helm,  Olivier Y.F. Henry,  Amir Bein,  Tiama Hamkins-Indik,  Michael J. Cronce,  William D. Leineweber,  Mathieu Odijk,  Andries D. van der Meer,  Jan C.T. Eijkel,  Donald E. Ingber,  Albert van den Berg  and  Loes I. Segerink, Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy, Lab on a Chip (2019) 19, 452-463,  DOI: 10.1039/C8LC00129D

2018

Albert van den Berg, Christine L. Mummery, Robert Passier and Andries D. van der Meer, Personalised organs-on-chips: functional testing for precision medicine, Lab on a Chip (2018) The Royal Society of Chemistry. DOI: 10.1039/c8lc00827b

Pandora Pound and Merel Ritskes‑Hoitinga (2018) Review: Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail. J Transl Med 16(1):304.

Marcia A.M.M. Ferraz, Hoon Suk Rho, Daiane Hemerich, Heiko H.W. Henning, Helena T.A. van Tol, Michael Hölker, Urban Besenfelder, Michal Mokry, Peter L.A.M. Vos, Tom A.E. Stout, Séverine Le Gac & Bart M. Gadella, An oviduct-on-a-chip provides an enhanced in vitro environment for zygote genome reprogramming (2018) Nature Communications, DOI: 10.1038/s41467-018-07119-8

Huili Hu, Helmuth Gehart, Benedetta Artegiani, Carmen Lopez-Iglesias, Florijn Dekkers, Onur Basak, Johan van Es, Susana M. Chuva de Sousa Lopes, HarryBegthel, Jeroen Korving, Maaike van den Born, Chenhui Zou, Corrine Quirk, Luis Chiriboga, Charles M. Rice, Stephanie Ma, Anne Rios, Peter J. Peters, Ype P. de Jong, Hans Clevers. Long-term expansion of functional mouse and human hepatocytes as 3D organoids. Cell, 175,1591–1606, November 29 (2018) https://doi.org/10.1016/j.cell.2018.11.013

te Winkel, M. Grootse plannen met piepkleine organen. UMCG kennis in zicht (2018)

Older

Anja van de Stolpe, Robert H. Kauffmann. Innovative human-specific investigational approaches to autoimmune disease, RSC Advances (2015) 5, 18451 – 18463.

Mummery, C., van de Stolpe, A., Roelen, B., Clevers, H. (2014). Stem cells. Scientific facts and fiction, Elsevier, 2nd edition, ISBN: 978-0-12-411551-4

Mummery, C. (2014). Stamceltoerisme. Uitgave tgv de afsluiting van het studiejaar van HOVO, Universiteit Leiden op 20 juni 2014.

J. van den Eijnden-van Raaij, A. van de Stolpe en S. Claessens.Op weg naar klinische trials op een chip? Interne Geneeskunde, 3 – 2014.

Anja van de Stolpe and Jaap den Toonder. Workshop meeting report Organs-on-Chips: human disease models, Lab Chip (2013) 13, 3449–3470.

Mummery, C., Wilmut, I., van de Stolpe, A., Roelen, B.A.J. (2011). Stem cells. Scientific facts and fiction, Elsevier, 1st edition, ISBN: 978-0-12-381535-4

Mummery, C., van de Stolpe, A. en Roelen, B. (2006). Stamcellen. Natuurwetenschap en Techniek, uitgeverij Veen Magazines, ISBN: 9085710367