Peer-reviewed publications of hDMT researchers about topics related to Microphysiological Systems and Organ-on-Chip technology are listed below.

Information about research topics of PhD students who graduated within the hDMT partner organizations is available via the button ‘PhD theses’.

For publications with a broader scope, including review papers, showcases, regulatory aspects, workshop reports, whitepapers etc, from researchers within hDMT or beyond, please scroll through the list of ‘Core publications’.


Orlova VV, Mummery CL.Cell Res. 2021 Sep;31(9):947-948. doi: 10.1038/s41422-021-00534-5.PMID: 34267348 Heart defects recapitulated in human cardioids.

Rodríguez Ruiz A, Dicks A, Tuerlings M, Schepers K, van Pel M, Nelissen RGHH, Freund C, Mummery CL, Orlova V, Guilak F, Meulenbelt I, Ramos YFM.Cell Tissue Res. 2021 Nov;386(2):309-320. doi: 10.1007/s00441-021-03498-5. Epub 2021 Jul 9.PMID: 34241697 Cartilage from human-induced pluripotent stem cells: comparison with neo-cartilage from chondrocytes and bone marrow mesenchymal stromal cells.

Wagstaff, P. et al. (2021) An alternative approach to produce versatile retinal organoids with accelerated ganglion cell development (Scientific Reports)

Brinks, J. et al. (2021) Exploring the choroidal vascular labyrinth and its molecular and structural roles in health and disease (Progress in Retinal and Eye Research)

Brinks, J. et al. (2021) The Cortisol Response of Male and Female Choroidal Endothelial Cells: Implications for Central Serous Chorioretinopathy (J Clin Endocrinology & Metabolism)

Philip E. Wagstaff, Anneloor L. M. A. ten Asbroek, Jacoline B. ten Brink, Nomdo M. Jansonius & Arthur A. Bergen (2021) An alternative approach to produce versatile retinal organoids with accelerated ganglion cell development. Scientific Reports volume 11, Article number: 1101 (PMID: 33441707)

Bogunovic, N. et al. (2021) Patient-Specific 3-Dimensional Model of Smooth Muscle Cell and Extracellular Matrix Dysfunction for the Study of Aortic Aneurysms (Journal of Endovascular Therapy)

Venzac et al. (2021) PDMS curing inhibition on 3D printed-molds: Why? And, how to avoid it? (Analytical Chemistry)

Beekman, P. et al. (2021) Organosilicon uptake by biological membranes (Communications Biology)

Giordano L et al. (2021) Review: Microphysiological Systems to Recapitulate the Gut-Kidney Axis (Trends in Biotechnology)

Heinrich, M.A. et al. (2021) Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models (Advanced Drug Delivery Reviews)

Picollet-D’hahan, N. at al. (2021) Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication: Trends in Biotechnology ( (Trends in Biotech) 


Tang H, Abouleila Y, Si L, Ortega-Prieto AM, Mummery CL, Ingber DE, Mashaghi A.Trends Microbiol. 2020 Nov;28(11):934-946. doi: 10.1016/j.tim.2020.06.005. Epub 2020 Jul 13.PMID: 32674988 Human Organs-on-Chips for Virology.

Stein JM, Mummery CL, Bellin M.Stem Cell Reports. 2021 Sep 14;16(9):2049-2057. doi: 10.1016/j.stemcr.2020.11.013. Epub 2020 Dec 18.PMID: 3333843 Engineered models of the human heart: Directions and challenges.

Buikema, J. et al. (2020) Wnt signaling and removal of cell-cell contact synergistically induce massive expansion of functional human iPSC-cardiomyocytes (Cell Stem Cell)

Maas, R. et al. (2020) Massive expansion and cryopreservation of beating induced pluripotent stem cell-derived cardiomyocytes (Star protocols)

Maas, R., Lee, S., Harakalova, M., Snijders-Blok, C.,  Goodyer, W.R., Hjortnaes, J., Doevendans, P.A.F.M., van Laake, L.W., van der Velden, J., Asselbergs, F.W., Wu, J., Sluijter, J., Wu, S.M. and Buikema, J.W. (2020). Massive expansion and cryopreservation of beating induced pluripotent stem cell-derived cardiomyocytes. Star protocols 2:100334. 

Buikema, J.W., Lee, S., Goodyer, W.R., Maas, R.G., Chirikian, O., Li, G., Miao, Y., Paige, S.L., Lee, D., Wu, H., Paik, D.T., Rhee, S., Tian, L., Galdos, F.X., Puluca, N., Beyersdorf, B., Hu, J., Beck, A., Venkamatran, S., Swami, S., Wijnker, P., Schuldt, M., Dorsch, L.M., van Mil, A., Red-Horse, K., Wu, J.Y., Geisen, C., Hesse, M., Serpooshan, V., Jovinge, S., Fleischmann, B.K., Doevendans, P.A., van der Velden, J., Garcia, K.C., Wu, J.C., Sluijter, J.P.G. and Wu, S.M. (2020). Wnt signaling and removal of cell-cell contact synergistically induce massive expansion of functional human iPSC-cardiomyocytes. Cell Stem Cell  27:50-63.e5. doi: 10.1016/j.stem.2020.06.001.

Akiva, A et al. (2020) An Organoid for Woven Bone (Wiley Online Library)

Juni, R.P. et al. (2020) Empagliflozin restores chronic kidney disease-induced impairment of endothelial regulation of cardiomyocyte relaxation and contraction (Kidney International)

Rodrigues, J et al. (2020) 3D In Vitro Model (R)evolution: Unveiling Tumor-Stroma Interactions
(Trends in Cancer)

Vincent van Duinen, Wendy Stam, Eva Mulder, Farbod Famili, Arie Reijerkerk, Paul Vulto, Thomas Hankemeier and Anton Jan van Zonneveld (2020) Robust and Scalable Angiogenesis Assay of Perfused 3D Human iPSC-Derived Endothelium for Anti-Angiogenic Drug Screening, Int. J. Mol. Sci., 21 (13), 4804.

Abidemi Junaid, Johannes Schoeman, Wei Yang, Wendy Stam, Alireza Mashagh1, Anton Jan van Zonneveld, Thomas Hankemeier (2020) Metabolic response of blood vessels to TNFa, eLife 2020; 9:e54754.

Lucie A. Low, Christine Mummery, Brian R. Berridge, Christopher P. Austin & Danilo A. Tagle (2020) Organs-on-chips: into the next decade, Nature Reviews Drug Discovery

Liu J, Li P, Wang L, Li M, Ge Z, Noordam L, Lieshout R, Verstegen MMA, Ma B, Su J, Yang Q, Zhang R, Zhou G, Carrascosa LC, Sprengers D, IJzermans JNM, Smits R, Kwekkeboom J, van der Laan LJW, Peppelenbosch MP, Pan Q, Cao W. (2020) Cancer-associated fibroblasts provide a stromal niche for liver cancer organoids that confers trophic effects and therapy resistance. Cell Mol Gastroenterol Hepatol. Sep 12:S2352-345X(20)30140-5. Online ahead of print.

Sunrui Chen, Pengfei Li, Yining Wang, Yuebang Yin, Petra E. de Ruiter, Monique M. A. Verstegen, Maikel P. Peppelenbosch, Luc J. W. van der Laan, Qiuwei Pan (2020) Rotavirus Infection and Cytopathogenesis in Human Biliary Organoids Potentially Recapitulate Biliary Atresia Development. mBio. Aug 25;11(4):e01968-20.

Kunst RF, Niemeijer M, van der Laan LJW, Spee B, van de Graaf SFJ. (2020) From fatty hepatocytes to impaired bile flow: Matching model systems for liver biology and disease. Biochem Pharmacol.  Jul 25;180:114173.

Melanie Krüger, Loes A. Oosterhoff, Monique E. van Wolferen, Simon A. Schiele, Andreas Walther, Niels Geijsen, Laura De Laporte, Luc J. W. van der Laan, Linda M. Kock, Bart Spee (2020). Cellulose Nanofibril Hydrogel Promotes Hepatic Differentiation of Human Liver Organoids. Adv Healthc Mater. Mar;9(6):e1901658.

Umber Saleem, Berend J van Meer, Puspita A Katili, Nurul A N Mohd Yusof, Ingra Mannhardt, Ana Krotenberg Garcia, Leon Tertoolen, Tessa de Korte, Maria LH Vlaming, Karen McGlynn, Jessica Nebel, Anthony Bahinski, Kate Harris, Eric Rossman, Xiaoping Xu, Francis L Burton, Godfrey L Smith, Peter Clements, Christine L Mummery, Thomas Eschenhagen, Arne Hansen, Chris Denning(2020) Blinded, multi-centre evaluation of drug-induced changes in contractility using human induced pluripotent stem cell-derived cardiomyocytes (2020) Toxicological Sciences, 176, Issue 1, 103–123.

Zhang, S., Cui, Z., Wang, Y. & Toonder, J.M.J. den (2020). Metachronal actuation of microscopic magnetic artificial cilia generates strong microfluidic pumping. Lab Chip.    

Zhang, S., Zhang, R., Wang, Y., Onck, P.R. & Toonder, J.M.J. den (2020). Controlled multidirectional particle transportation by magnetic artificial cilia. ACS Nano. 

Pilz da Cunha, M., Kandail, H.S.., Toonder, J.M.J. & Schenning, A.P.H.J. (2020). An artificial aquatic polyp that wirelessly attracts, grasps, and releases objects. PNAS.

Zhang, S., Wang, Y., Onck, P.R. & Toonder, J.M.J. den (2020). Anti-Biofouling and Self-Cleaning Surfaces Featured with Magnetic Artificial Cilia. ACS Appl. Mater. Interfaces.  

Pilz da Cunha, M., Ambergen, S., Debije, M.G., Homburg, F.G.A., Toonder, J.M.J. & Schenning, A.P.H.J. (2020). A soft transporter robot fueled by light. Advanced Science.

Alessandro Iuliano, Erik van der Wal, Claudine W.B. Ruijmbeek, Stijn L.M. in ‘t Groen, Pim Pijnappel, Jessica C. de Greef and Vittorio Saggiomo (2020) Coupling 3D Printing and Novel Replica Molding for In House Fabrication of Skeletal Muscle Tissue Engineering Devices, Advanced Materials Technologies.

Milica Dostanić, Laura M Windt, Jeroen M Stein, Berend J van Meer, Milena Bellin, Valeria Orlova, Massimo Mastrangeli, Christine L Mummery, Pasqualina M Sarro, (2020) A Miniaturized EHT Platform for Accurate Measurements of Tissue Contractile Properties, Journal of Microelectromechanical Systems.

Mart Lamers, Joep Beumer, […] Peter Peters, Bart Haagmans and Hans Clevers. SARS-CoV-2 productively Infects Human Gut Enterocytes. Science, 1 May 2020.

Longlong Si, Haiqing Bai, […] Donald Ingber (2020) Human organs-on-chips as tools for repurposing approved drugs as potential influenza and COVID-19 therapeutics in viral pandemics. Posted April 15, 2020.

Abidemi Junaid, Huaqi Tang […] Anton Jan van Zonneveld, Thomas Hankemeier and Alireza Mashaghi (2020) Ebola Hemorrhagic Shock Syndrome-on-a-ChipiScience 23(1):100765.

Carlo Alberto Paggi, Bastien Venzac, Marcel Karperien, Jeroen C.H. Leijten and Séverine Le Gac (2020) Monolithic microfluidic platform for exerting gradients of compression on cell-laden hydrogels, and application to a model of the articular cartilage. Sensors and Actuators B: Chemical, Vol 315, 15, 127917.

Marcia de Almeida Monteiro Melo Ferraz, Jennifer Beth Nagashima, Bastien Venzac, Séverine Le Gac & Nucharin Songsasen (2020) A dog oviduct-on-a-chip model of serous tubal intraepithelial carcinomaScientific Reports, vol 10, no 1575.

Marcia de Almeida Monteiro Melo Ferraz, Jennifer Beth Nagashima, Bastien Venzac, Séverine Le Gac & Nucharin Songsasen (2020) 3D printed mold leachates in PDMS microfluidic devices. Scientific Reports, vol 10, no 994.


Garrett Ainslie, Myrtle Davis, […] and Anne Ryan (2019) Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: a biopharmaceutical perspective, Lab on a Chip, 19, 3152-3161.

Frans Schutgens, Maarten Rookmaaker, […] and Hans Clevers, (2019) Tubuloids derived from human adult kidney and urine for personalized disease modelingNature Biotechnology 37, 303–313.

Floris van den Brink, Thas Phisonkunkasem, […] and  Mathieu Odijk (2019) A miniaturized push–pull-perfusion probe for few-second sampling of neurotransmitters in the mouse brainLab on a Chip 19, 1332-1343.

Zhang, S., Wang, Y., Onck, P. R., & den Toonder, J. M. J. (2019). Removal of microparticles by ciliated surfaces: an experimental study. Advanced Functional Materials, 29(6), [1806434].

Buskermolen, A. B. C., Suresh, H., Shishvan, S. S., Vigliotti, A., DeSimone, A., Kurniawan, N. A., … Deshpande, V. S. (2019). Entropic forces drive cellular contact guidance. Biophysical Journal.

van Kelle, M. A. J., Khalil, N., Foolen, J., Loerakker, S., & Bouten, C. V. C. (2019). Increased cell traction-induced prestress in dynamically cultured microtissues. Frontiers in Bioengineering and Biotechnology, 7, [41].

Wissing, T. B., Bonito, V., van Haaften, E. E., van Doeselaar, M., Brugmans, M. M. C. P., Janssen, H. M., … Smits, A. I. P. M. (2019). Macrophage-driven biomaterial degradation depends on scaffold microarchitecture. Frontiers in Bioengineering and Biotechnology, 7(APR), [87]. DOI: 10.3389/fbioe.2019.00087

Marinke W. van der Helm,  Olivier Y.F. Henry,  Amir Bein,  Tiama Hamkins-Indik,  Michael J. Cronce,  William D. Leineweber,  Mathieu Odijk,  Andries D. van der Meer,  Jan C.T. Eijkel,  Donald E. Ingber,  Albert van den Berg  and  Loes I. Segerink, Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy, Lab on a Chip (2019) 19, 452-463,  DOI: 10.1039/C8LC00129D


Albert van den Berg, Christine L. Mummery, Robert Passier and Andries D. van der Meer, Personalised organs-on-chips: functional testing for precision medicineLab on a Chip (2018) The Royal Society of Chemistry. DOI: 10.1039/c8lc00827b

Pandora Pound and Merel Ritskes‑Hoitinga (2018) Review: Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail. J Transl Med 16(1):304.

Marcia A.M.M. Ferraz, Hoon Suk Rho, Daiane Hemerich, Heiko H.W. Henning, Helena T.A. van Tol, Michael Hölker, Urban Besenfelder, Michal Mokry, Peter L.A.M. Vos, Tom A.E. Stout, Séverine Le Gac & Bart M. Gadella, An oviduct-on-a-chip provides an enhanced in vitro environment for zygote genome reprogramming (2018) Nature Communications, DOI: 10.1038/s41467-018-07119-8

Huili Hu, Helmuth Gehart, Benedetta Artegiani, Carmen Lopez-Iglesias, Florijn Dekkers, Onur Basak, Johan van Es, Susana M. Chuva de Sousa Lopes, HarryBegthel, Jeroen Korving, Maaike van den Born, Chenhui Zou, Corrine Quirk, Luis Chiriboga, Charles M. Rice, Stephanie Ma, Anne Rios, Peter J. Peters, Ype P. de Jong, Hans Clevers. Long-term expansion of functional mouse and human hepatocytes as 3D organoids. Cell, 175,1591–1606, November 29 (2018)

te Winkel, M. Grootse plannen met piepkleine organen. UMCG kennis in zicht (2018)


Anja van de Stolpe, Robert H. Kauffmann. Innovative human-specific investigational approaches to autoimmune disease, RSC Advances (2015) 5, 18451 – 18463.

Mummery, C., van de Stolpe, A., Roelen, B., Clevers, H. (2014). Stem cells. Scientific facts and fiction, Elsevier, 2nd edition, ISBN: 978-0-12-411551-4

Mummery, C. (2014). Stamceltoerisme. Uitgave tgv de afsluiting van het studiejaar van HOVO, Universiteit Leiden op 20 juni 2014.

J. van den Eijnden-van Raaij, A. van de Stolpe en S. Claessens.Op weg naar klinische trials op een chip? Interne Geneeskunde, 3 – 2014.

Anja van de Stolpe and Jaap den Toonder. Workshop meeting report Organs-on-Chips: human disease models, Lab Chip (2013) 13, 3449–3470.

Mummery, C., Wilmut, I., van de Stolpe, A., Roelen, B.A.J. (2011). Stem cells. Scientific facts and fiction, Elsevier, 1st edition, ISBN: 978-0-12-381535-4

Mummery, C., van de Stolpe, A. en Roelen, B. (2006). Stamcellen. Natuurwetenschap en Techniek, uitgeverij Veen Magazines, ISBN: 9085710367