Angelo Accardo (TU Delft) has received a grant entitled ‘ Shaping the blood brain/tumor barrier using light’ from the NWO Domain Board Science in the Open Competition Domain Science – XS.
The blood brain barrier (BBB) plays a crucial role in various neurological diseases (e.g., brain tumors, Alzheimer’s, multiple sclerosis). Although its selective permeability is vital to preserve brain functions, it also hinders the diffusion of drugs to their targets. To date, there is not a 3D model of the BBB, which holistically incorporates its geometric, biochemical and flow features. The group of Accardo will pioneer this model by combining cell-culture with laser-assisted 3D printing and microfluidics, and apply it to patient malignant brain cancer (gliomas). The results will pave the way for the assessment of glioma treatments (e.g., drug delivery or immunotherapy).
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Illustration: foto Accardo
