Kick-off for project RAAK-PRO grant on Organs-on-Chips at Leiden Center for Applied Bioscience

On February 28th 2024 the RAAK-PRO project: ‘Development of Analytical-Chemical methods for drug research with Organs-on-Chips (AC/OC)’ kicked off at the University of Applied Sciences in Leiden.

The RAAK-PRO project ‘Development of Analytical-Chemical methods for drug research with Organs-on-Chips (AC/OC) was awarded to the Research Group Metabolomics of the Leiden Centre for Applied Bioscience.

The grant, funded by Regieorgaan SIA was awarded to the Research group Metabolomics at Leiden Centre for Applied Bioscience.

The AC/OC project aims to develop and enhance analytical-chemical methods, particularly in the realm of liquid chromatography coupled with mass spectrometry (LC-MS). These techniques empower researchers to measure critical pharmacokinetic parameters, such as absorption, distribution, metabolism, and excretion (ADME), in various OoC models.

Interdisciplinary AC/OC consortium

This project will not only improve the efficiency and reliability of drug research but also lay the foundation for the development of a minor program called ‘OoC-Technology.’ This program translates research findings into education, equipping professionals with the necessary knowledge and skills for this rapidly evolving field.

Under the leadership of the research group Metabolomics at Leiden Centre for Applied Bioscience, the project is executed in collaboration with esteemed partners, including: Leiden University – Leiden Academic Centre for Drug Research (LACDR), Leiden University Medical Center (LUMC), Utrecht University of Applied Sciences, TNO, Mimetas – The Organ-on-a-Chip company, Interscience BV, Proefdiervrij, Crown Biosciences, Centre for Human Drug Research, hDMT, and Bruker.

Peter Lindenburg, Project Lead, expressed, “With this grant, we can conduct four years of state-of-the-art practice-oriented research. We are excited to begin working with our partners and look forward to a successful outcome.”

The Leiden Centre for Applied Bioscience (LCAB) is the knowledge center of the Faculty of Science & Technology at Leiden University of Applied Sciences. It conducts practice-oriented research on topics within the theme of Biodiversity and Health.

Source: University or Applied Sciences Leiden

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